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動脈硬化疾患における単球膜上トールライクレセプター発現量の検討
http://hdl.handle.net/10232/11998
http://hdl.handle.net/10232/11998c9a06b62-7607-4fb3-ac69-84fd8867cd39
名前 / ファイル | ライセンス | アクション |
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20590831seika.pdf (278.6 kB)
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Item type | 研究報告書 / Research Paper(1) | |||||
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公開日 | 2015-01-06 | |||||
タイトル | ||||||
タイトル | 動脈硬化疾患における単球膜上トールライクレセプター発現量の検討 | |||||
タイトルよみ | ||||||
タイトルよみ | ドウミャク コウカ シッカン ニオケル タンキュウ マクジョウ トールライク レセプター ハツゲンリョウ ノ ケントウ | |||||
別言語のタイトル | ||||||
その他のタイトル | Toll-like receptor expression level on circulating monocyte in atherosclerotic disease | |||||
著者 |
折原, 弘治
× 折原, 弘治 |
|||||
著者よみ | ||||||
姓名 | オリハラ, コウジ | |||||
別言語の著者 | ||||||
姓名 | ORIHARA, Koji | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 臨床 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 内科 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 循環器・高血圧 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 感染症 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2008-2010年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号:20590831 研究代表者:折原弘治 (鹿児島大学大学院医歯学総合研究科特任助教) | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | TLR 2(トール様レセプター2) 高値が、周知の危険因子(喫煙習慣、糖尿病、高血圧、高脂血症)とは独立して、動脈硬化形成の一つのリスクファクターとみなすことができるか否かの検討を行った。結果、動脈硬化性疾患群では、単球膜上TLR2レベルは、そのコントロール群に比べて、有意に高かった。更なる解析の結果、TLR2レベルはその他の危険因子とは独立しており、新たな動脈硬化危険因子の一つであることが示唆された。 | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns to initiate an innate immune response. We previously reported upregulation of TLR2 expression level on monocytes of stable angina pectoris patients with significant coronary artery disease (CAD) relative to control patients without significant CAD. In this study we aimed to determine whether high level of Toll-like receptor 2 (TLR2) is a risk factor for atherogenesis, independent of established risk factors including smoking, diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL).TLR2 expression level on circulating monocyte surfaces was measured by using our developed flow cytometry assay. Patients were classified into two roups: "Arteriosclerotic disease" group (n=108) and "Control" group (n=70). Patients of the first group had arteriosclerotic disease such as CAD, aortic aneurysm, or peripheral arterial disease (PAD). The "Control" group was sex- and age-matched to the "Arteriosclerotic disease" group. The results demonstrated that TLR2 expression was significantly higher in the "Arteriosclerotic disease" group than in the "Control" group (p<0.001). Multivariate ordinal logistic regression analysis was performed; other known risk factors, which were represented to two nominal score points, 0 or 1, for patients with and without it, respectively, and TLR2 level, which was treated as a metric variable. DM (p=0.002), HT (p=0.001), HL (p<0.001), and TLR2 level (p<0.001) were identified as significant contributors for arteriosclerotic disease. In conclusion, high TLR2 expression level on monocytes may be an independent risk factor for atherogenesis. | |||||
作成日 | ||||||
日付 | 2011-05-31 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NDC | ||||||
主題Scheme | NDC | |||||
主題 | 493 | |||||
公開者・出版者 | ||||||
出版者 | 鹿児島大学 | |||||
公開者よみ | ||||||
公開者よみ | カゴシマ ダイガク | |||||
公開者別名 | ||||||
公開者別名 | Kagoshima University | |||||
科研費番号 | ||||||
20590831 |