WEKO3
アイテム
{"_buckets": {"deposit": "78a45859-069c-42d4-8559-45a2e311880d"}, "_deposit": {"created_by": 18, "id": "15626", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "15626"}, "status": "published"}, "_oai": {"id": "oai:ir.kagoshima-u.ac.jp:00015626", "sets": ["86"]}, "author_link": ["138181"], "item_5_date_6": {"attribute_name": "作成日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2020-11-05", "subitem_date_issued_type": "Collected"}]}, "item_5_date_granted_54": {"attribute_name": "学位授与年月日 ", "attribute_value_mlt": [{"subitem_dategranted": "2020-11-13"}]}, "item_5_degree_grantor_53": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "鹿児島大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "17701", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_5_degree_name_42": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(歯学)", "subitem_degreename_language": "ja"}, {"subitem_degreename": "Doctor of Philosophy in Dental Science", "subitem_degreename_language": "en"}]}, "item_5_description_17": {"attribute_name": "ファイル(説明)", "attribute_value_mlt": [{"subitem_description": "博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_5_description_4": {"attribute_name": "要約(Abstract)", "attribute_value_mlt": [{"subitem_description": "LL-37, the only member of the cathelicidin family of cationic antimicrobial peptides in humans has been shown to exhibit a wide variety of biological actions in addition to its antimicrobial activity. However, the lymphangiogenic effect of LL-37 has not been elucidated yet. In this study, we examined the effects of LL-37 on lymphangiogenesis and evaluated the underlying molecular mechanisms. LL-37 treatment significantly increased the migration and tube-like formation of human dermal lymphatic microvascular endothelial cells (HDLECs) and promoted the expression of lymphangiogenic factor in HDLECs. Treatment with LL-37 increased phosphorylation of ERK and Akt proteins in HDLECs, and pretreatment with ERK and Akt inhibitors significantly blocked the LL-37-induced HDLEC migration and tube-like formation. Furthermore, to investigate the involvement of formyl peptide receptor-like 1 (FPRL1) signaling in LL-37-induced lymphangiogenesis, HDLECs were treated with an FPRL1 antagonist. Pretreatment with the FPRL1 antagonist inhibited LL-37-induced phosphorylation of ERK and Akt proteins and attenuated LL-37-induced HDLEC migration and tube-like formation. These data indicated that LL-37 induces lymphangiogenesis in lymphatic endothelial cells via FPRL1, and the activation of the ERK and Akt-dependent signaling pathways.\n\nTakahiro Yanagisawa, Masakazu Ishii, Manami Takahashi, Kei Fujishima \u0026 Masahiro Nishimura \nHuman cathelicidin antimicrobial peptide LL-37 promotes lymphangiogenesis in lymphatic endothelial cells through the ERK and Akt signaling pathways\nMolecular Biology Reports volume 47, pages6841–6854 (2020)\nThis is a post-peer-review, pre-copyedit version of an article published in Molecular Biology Reports . \nThe final authenticated version is available online at: \nhttps://doi.org/10.1007/s11033-020-05741-8", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_5_dissertation_number_55": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲総研第579号"}]}, "item_5_publisher_23": {"attribute_name": "公開者・出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer", "subitem_publisher_language": "en"}, {"subitem_publisher": "鹿児島大学", "subitem_publisher_language": "ja"}, {"subitem_publisher": "カゴシマ ダイガク", "subitem_publisher_language": "ja-Kana"}]}, "item_5_subject_15": {"attribute_name": "NDC", "attribute_value_mlt": [{"subitem_subject": "490", "subitem_subject_scheme": "NDC"}]}, "item_5_text_44": {"attribute_name": "備考", "attribute_value_mlt": [{"subitem_text_value": "【指導教員:西村正宏】 "}]}, "item_5_text_47": {"attribute_name": "date.appl", "attribute_value_mlt": [{"subitem_text_value": "【学位申請日】2020-10-07"}]}, "item_5_version_type_14": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "柳澤, 嵩大", "creatorNameLang": "ja"}, {"creatorName": "ヤナギサワ, タカヒロ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Yanagisawa, Takahiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "138181", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-10-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Diss_柳澤_嵩大_ISK579_2020.pdf", "filesize": [{"value": "834.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 834700.0, "url": {"label": "Diss_柳澤_嵩大_ISK579_2020", "objectType": "fulltext", "url": "https://ir.kagoshima-u.ac.jp/record/15626/files/Diss_柳澤_嵩大_ISK579_2020.pdf"}, "version_id": "1196c04a-47d2-45c7-9b03-157be5a5d4e9"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-09"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "Abstract_柳澤_嵩大_4516810414_2020.pdf", "filesize": [{"value": "24.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 24500.0, "url": {"label": "Abstract_柳澤_嵩大_4516810414_2020", "objectType": "abstract", "url": "https://ir.kagoshima-u.ac.jp/record/15626/files/Abstract_柳澤_嵩大_4516810414_2020.pdf"}, "version_id": "9e8858d9-de1b-49f5-b412-6244a28dd351"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-03"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "Result_Yanagisawa_Takahiro_isk_579.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "Result_Yanagisawa_Takahiro_isk_579", "objectType": "other", "url": "https://ir.kagoshima-u.ac.jp/record/15626/files/Result_Yanagisawa_Takahiro_isk_579.pdf"}, "version_id": "541211d3-0525-4f88-83a5-bf7ac07cecdd"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-03"}], "displaytype": "detail", "download_preview_message": "", "file_order": 3, "filename": "Comments_Yanagisawa_Takahiro_isk_579.pdf", "filesize": [{"value": "492.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 492800.0, "url": {"label": "Comments_Yanagisawa_Takahiro_isk_579", "objectType": "other", "url": "https://ir.kagoshima-u.ac.jp/record/15626/files/Comments_Yanagisawa_Takahiro_isk_579.pdf"}, "version_id": "2bc0df9c-679f-41a2-a9a4-732eefd8ddb2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "LL-37", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lymphangiogenesis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ERK", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Akt", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "FPRL1", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Human Cathelicidin Antimicrobial Peptide LL-37 Promotes Lymphangiogenesis in Lymphatic Endothelial Cells through the ERK and Akt Signaling Pathways", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Human Cathelicidin Antimicrobial Peptide LL-37 Promotes Lymphangiogenesis in Lymphatic Endothelial Cells through the ERK and Akt Signaling Pathways", "subitem_title_language": "en"}, {"subitem_title": "ヒトカテリシジン抗菌性ペプチドLL-37はERK及びAktシグナル伝達経路を介してリンパ管内皮細胞によるリンパ管新生を促進する", "subitem_title_language": "ja"}]}, "item_type_id": "5", "owner": "18", "path": ["86"], "permalink_uri": "http://hdl.handle.net/10232/00031514", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-12-03"}, "publish_date": "2020-12-03", "publish_status": "0", "recid": "15626", "relation": {}, "relation_version_is_last": true, "title": ["Human Cathelicidin Antimicrobial Peptide LL-37 Promotes Lymphangiogenesis in Lymphatic Endothelial Cells through the ERK and Akt Signaling Pathways"], "weko_shared_id": -1}
ヒトカテリシジン抗菌性ペプチドLL-37はERK及びAktシグナル伝達経路を介してリンパ管内皮細胞によるリンパ管新生を促進する
http://hdl.handle.net/10232/00031514
http://hdl.handle.net/10232/00031514afc7a1b4-412f-4351-a5a8-4068879f23cd
名前 / ファイル | ライセンス | アクション |
---|---|---|
Diss_柳澤_嵩大_ISK579_2020 (834.7 kB)
|
|
|
Abstract_柳澤_嵩大_4516810414_2020 (24.5 kB)
|
|
|
Result_Yanagisawa_Takahiro_isk_579 (1.1 MB)
|
|
|
Comments_Yanagisawa_Takahiro_isk_579 (492.8 kB)
|
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-12-03 | |||||
タイトル | ||||||
タイトル言語 | en | |||||
タイトル | Human Cathelicidin Antimicrobial Peptide LL-37 Promotes Lymphangiogenesis in Lymphatic Endothelial Cells through the ERK and Akt Signaling Pathways | |||||
タイトル | ||||||
タイトル言語 | ja | |||||
タイトル | ヒトカテリシジン抗菌性ペプチドLL-37はERK及びAktシグナル伝達経路を介してリンパ管内皮細胞によるリンパ管新生を促進する | |||||
著者 |
柳澤, 嵩大
× 柳澤, 嵩大 |
|||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | LL-37 | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | Lymphangiogenesis | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | ERK | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | Akt | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | FPRL1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | LL-37, the only member of the cathelicidin family of cationic antimicrobial peptides in humans has been shown to exhibit a wide variety of biological actions in addition to its antimicrobial activity. However, the lymphangiogenic effect of LL-37 has not been elucidated yet. In this study, we examined the effects of LL-37 on lymphangiogenesis and evaluated the underlying molecular mechanisms. LL-37 treatment significantly increased the migration and tube-like formation of human dermal lymphatic microvascular endothelial cells (HDLECs) and promoted the expression of lymphangiogenic factor in HDLECs. Treatment with LL-37 increased phosphorylation of ERK and Akt proteins in HDLECs, and pretreatment with ERK and Akt inhibitors significantly blocked the LL-37-induced HDLEC migration and tube-like formation. Furthermore, to investigate the involvement of formyl peptide receptor-like 1 (FPRL1) signaling in LL-37-induced lymphangiogenesis, HDLECs were treated with an FPRL1 antagonist. Pretreatment with the FPRL1 antagonist inhibited LL-37-induced phosphorylation of ERK and Akt proteins and attenuated LL-37-induced HDLEC migration and tube-like formation. These data indicated that LL-37 induces lymphangiogenesis in lymphatic endothelial cells via FPRL1, and the activation of the ERK and Akt-dependent signaling pathways. Takahiro Yanagisawa, Masakazu Ishii, Manami Takahashi, Kei Fujishima & Masahiro Nishimura Human cathelicidin antimicrobial peptide LL-37 promotes lymphangiogenesis in lymphatic endothelial cells through the ERK and Akt signaling pathways Molecular Biology Reports volume 47, pages6841–6854 (2020) This is a post-peer-review, pre-copyedit version of an article published in Molecular Biology Reports . The final authenticated version is available online at: https://doi.org/10.1007/s11033-020-05741-8 |
|||||
内容記述言語 | en | |||||
作成日 | ||||||
日付 | 2020-11-05 | |||||
日付タイプ | Collected | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NDC | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
言語 | ja | |||||
公開者・出版者 | ||||||
出版者言語 | en | |||||
出版者 | Springer | |||||
公開者・出版者 | ||||||
出版者言語 | ja | |||||
出版者 | 鹿児島大学 | |||||
公開者・出版者 | ||||||
出版者言語 | ja-Kana | |||||
出版者 | カゴシマ ダイガク | |||||
備考 | ||||||
備考 | 【指導教員:西村正宏】 | |||||
date.appl | ||||||
【学位申請日】2020-10-07 | ||||||
学位名 | ||||||
学位名の言語 | ja | |||||
学位名 | 博士(歯学) | |||||
学位名 | ||||||
学位名の言語 | en | |||||
学位名 | Doctor of Philosophy in Dental Science | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17701 | |||||
学位授与機関名の言語 | ja | |||||
学位授与機関名 | 鹿児島大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2020-11-13 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲総研第579号 |