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新規脊髄損傷再生療法による損傷神経回路網再建メカニズムの解明
http://hdl.handle.net/10232/14792
http://hdl.handle.net/10232/14792b35f768b-e45a-42f1-8057-4897ad4c9786
名前 / ファイル | ライセンス | アクション |
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22791381seika.pdf (229.3 kB)
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Item type | 研究報告書 / Research Paper(1) | |||||
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公開日 | 2014-12-24 | |||||
タイトル | ||||||
タイトル | 新規脊髄損傷再生療法による損傷神経回路網再建メカニズムの解明 | |||||
タイトルよみ | ||||||
タイトルよみ | シンキ セキズイ ソンショウ サイセイ リョウホウ ニヨル ソンショウ シンケイ カイロモウ サイケン メカニズム ノ カイメイ | |||||
別言語のタイトル | ||||||
その他のタイトル | Regenerative therapy for spinal cord injury and their mechanism for reconstruction | |||||
著者 |
棈松, 昌彦
× 棈松, 昌彦 |
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著者よみ | ||||||
姓名 | アベマツ, マサヒコ | |||||
別言語の著者 | ||||||
姓名 | ABEMATSU, Masahiko | |||||
別言語の著者 | ||||||
姓名 | あべ松, 昌彦 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 脊椎脊髄病学 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2010-2011年度科学研究費助成事業(科学研究費補助金(若手研究(B)))研究成果報告書 課題番号:22791381 研究代表者:棈松昌彦 (鹿児島大学医学部・歯学部附属病院医員) | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 重度脊髄損傷などの壊れた中枢神経回路網の再建は非常に難しく、根本的な治療法は未だに確立していない。我々は神経幹細胞と抗てんかん薬を併用して効率よく神経細胞をつくり、重度脊髄損傷マウスが歩行可能になる治療法を開発するとともに、このときに働く新たな治癒メカニズムを明らかにしたので報告する。 | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Neural stem cells (NSCs) possess the ability to self-renew and to differentiate into the three major cell types found in the central nervous system (CNS). Recent studies have shown that epigenetic gene regulation events such as DNA methylation and histone modification play important roles in regulating NSC fate specification. In this context, we have previously shown that the histone deacetylase inhibitor valproic acid (VPA) enhances neuronal differentiation of NSCs. Perhaps because these patterns of NSC differentiation are exquisitely controlled during normal embryonic development, restoration of damaged neural networks in the injured adult CNS is severely limited. Here, using a mouse model of spinal cord injury(SCI), we examined the effectiveness of NSC transplantation and differentiation control by VPA administration. | |||||
作成日 | ||||||
日付 | 2012-04-20 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NDC | ||||||
主題Scheme | NDC | |||||
主題 | 494 | |||||
公開者・出版者 | ||||||
出版者 | 鹿児島大学 | |||||
公開者よみ | ||||||
公開者よみ | カゴシマ ダイガク | |||||
公開者別名 | ||||||
公開者別名 | Kagoshima University | |||||
科研費番号 | ||||||
22791381 |