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肺動脈性肺高血圧症患者における肺MIBG取り込み低下
http://hdl.handle.net/10232/00029887
http://hdl.handle.net/10232/000298876e6af19c-fa8e-4817-af80-4f4362ddeeee
名前 / ファイル | ライセンス | アクション |
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Diss_肥後_建樹郎_ISK429_2017 (1.2 MB)
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Result_Higo_Kenjuro_isk429_2017 (135.5 kB)
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Comments_Higo_Kenjuro_isk429_2017 (69.5 kB)
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Abstruct_肥後_建樹郎_4513810331_2017 (100.3 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2017-10-10 | |||||
タイトル | ||||||
タイトル言語 | en | |||||
タイトル | Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension | |||||
タイトル | ||||||
タイトル言語 | ja | |||||
タイトル | 肺動脈性肺高血圧症患者における肺MIBG取り込み低下 | |||||
著者 |
肥後, 建樹郎
× 肥後, 建樹郎 |
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言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | Pulmonary hypertension | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | 123I-MIBG scintigraphy | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | Endothelial dysfunction | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | According to recent studies, lung uptake of iodine-123-metaiodobenzylguanidine (123I-MIBG) is impaired in many lung diseases and low lung uptake of 123I-MIBG suggests endothelial dysfunction of the pulmonary artery.123I-MIBG scintigraphy in patients with pulmonary hypertension (PH) has not yet been clinically evaluated. We hypothesized that the lung uptake of 123I-MIBG is reduced in patients with PH and differs among PH subtypes. The purpose of the present study was to analyze the lung uptake of 123I-MIBG in patients with PH and compare it with the data obtained by echocardiography or right heart catheterization. 123I-MIBG scintigraphy was performed in 286 consecutive patients from 2003 to 2014. We enrolled 21 patients with PH and 8 control patients.The 21 patients with PH were categorized into those with pulmonary artery hypertension(PAH, n=12) and those with chronic thromboembolic pulmonary hypertension (CTEPH, n=9). The mean pulmonary artery pressure was not significantly different between patients with CTEPH and PAH (37.7 ± 6.8 versus 32.3 ± 5.3 mmHg respectively; P=0.054). There were no significant differences in any other hemodynamic parameters between the two groups.The lung uptake of 123I-MIBG in PAH patients (early image: 1.54 ± 0.18, delayed image: 1.41 ± 0.16) was significantly lower than that of CTEPH patients (early image: 2.17 ± 0.25,P<0.0001; delayed image: 1.99 ± 0.20, P=0.0001, adjusted for ageand World Health Organization classification) and controls(early image: 2.32 ± 0.27, P=0.0007; delayed image: 1.92 ± 0.19,P=0.0007). In conclusion, we found for the first time that the lung uptake of 123I-MIBG in patients with PAH is lower than that in patients with CTEPH and controls. | |||||
内容記述言語 | en | |||||
収録雑誌名 |
en : International Heart Journal 巻 59, 号 1, p. 112-119, 発行日 2018 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 13492365 | |||||
権利 | ||||||
権利情報の言語 | en | |||||
権利情報 | © 2018 by the International Heart Journal Association | |||||
情報源 | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/ihj/ | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NDC | ||||||
主題Scheme | NDC | |||||
主題 | 493 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨 | |||||
言語 | ja | |||||
公開者・出版者 | ||||||
出版者言語 | en | |||||
出版者 | International Heart Journal Association | |||||
公開者・出版者 | ||||||
出版者言語 | ja | |||||
出版者 | 鹿児島大学 | |||||
公開者・出版者 | ||||||
出版者言語 | ja-Kana | |||||
出版者 | カゴシマ ダイガク | |||||
関連(hasPart) | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://doi.org/10.1536/ihj.16-629 | |||||
備考 | ||||||
備考 | 【指導教員:大石充】 | |||||
date.appl | ||||||
【学位申請日】2017-04-14 | ||||||
学位名 | ||||||
学位名の言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位名 | ||||||
学位名の言語 | en | |||||
学位名 | Doctor of Philosophy in Medical Science | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17701 | |||||
学位授与機関名の言語 | ja | |||||
学位授与機関名 | 鹿児島大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-09-29 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲総研第429号 |