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ヒト乳癌細胞株SK-BR-3において、PCP4/PEP19はCYP19A1 promoter I.1を介してaromatase遺伝子発現を亢進する。
http://hdl.handle.net/10232/00030543
http://hdl.handle.net/10232/0003054397cd0aa3-b282-48cd-99cc-86d30796abad
名前 / ファイル | ライセンス | アクション |
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Diss_本庄_希江_ISK506_2018 (5.5 MB)
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Abstract_本庄_希江_4515810151_2018 (92.8 kB)
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Result_Honjyo_Kie_isk_506 (893.6 kB)
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Comments_Honjyo_Kie_isk_506 (509.6 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-04-19 | |||||
タイトル | ||||||
タイトル言語 | en | |||||
タイトル | PCP4/PEP19 Upregulates Aromatase Gene Expression via CYP19A1 Promoter I.1 in Human Breast Cancer SK-BR-3 Cells | |||||
タイトル | ||||||
タイトル言語 | ja | |||||
タイトル | ヒト乳癌細胞株SK-BR-3において、PCP4/PEP19はCYP19A1 promoter I.1を介してaromatase遺伝子発現を亢進する。 | |||||
著者 |
本庄, 希江
× 本庄, 希江 |
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言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | PCP4/PEP19 | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | breast cancer | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | aromatase | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | intratumoral heterogeneity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Purkinje cell protein 4/peptide 19 (PCP4/PEP19) is a novel breast cancer cell expressing peptide, originally found in the neural cells as an anti-apoptotic factor, could inhibit cell apoptosis and enhance cell migration and invasion in human breast cancer cell lines. The expression of PCP4/PEP19 is induced by estrogens in estrogen receptor-positive (ER+) MCF-7 cells but also highly expressed in ER- SK-BR-3 cells. In this study, we investigated the effects of PCP4/PEP19 on aromatase gene expression in MCF-7 and SK-BR-3 human breast cancer cells. In SK-BR-3 cells but not in MCF-7 cells, PCP4/PEP19 knockdown by siRNA silencing decreased the aromatase expression in gene transcriptional level. When PCP4/PEP19 was overexpressed by CMV promoterdriven PCP4/PEP19 expressing plasmid transfection, aromatase gene transcription increased in SK-BR-3 cells. This aromatase gene transcription is mainly mediated through promoter region PI.1, which is usually active in the placental tissue but not in the breast cancer tissue. These results indicate a new function of PCP4/PEP19 that would enhance aromatase gene upregulation to supply estrogens in heterogeneous cancer microenvironment. | |||||
内容記述言語 | en | |||||
収録雑誌名 |
en : Oncotarget 巻 9, 号 51, p. 29619-29633, 発行日 2018 |
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作成日 | ||||||
日付 | 2019-03-07 | |||||
日付タイプ | Collected | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
DOI | 10.18632/oncotarget.25651 | |||||
情報源 | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.oncotarget.com/ | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NDC | ||||||
主題Scheme | NDC | |||||
主題 | 494 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
言語 | ja | |||||
公開者・出版者 | ||||||
出版者言語 | en | |||||
出版者 | Oncotarget | |||||
公開者・出版者 | ||||||
出版者言語 | ja | |||||
出版者 | 鹿児島大学 | |||||
公開者・出版者 | ||||||
出版者言語 | ja-Kana | |||||
出版者 | カゴシマ ダイガク | |||||
備考 | ||||||
備考 | 【指導教員:中村典史】 | |||||
date.appl | ||||||
【学位申請日】2018-09-05 | ||||||
学位名 | ||||||
学位名の言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位名 | ||||||
学位名の言語 | en | |||||
学位名 | Doctor of Philosophy in Medical Science | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17701 | |||||
学位授与機関名の言語 | ja | |||||
学位授与機関名 | 鹿児島大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2019-03-25 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲総研第506号 |