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Lactobacillus plantarum 06CC2 の腸炎予防効果の検討
http://hdl.handle.net/10232/00031139
http://hdl.handle.net/10232/00031139b02c14d5-e80c-4376-9507-6b1defad1bd5
名前 / ファイル | ライセンス | アクション |
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Diss_田中_啓仁_ISK565_2020 (1.4 MB)
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Abstract_田中_啓仁_4509800196_2019 (162.1 kB)
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Result_Tanaka_Akihito_isk_565 (1.2 MB)
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Comments_Tanaka_Akihito_isk_565 (439.8 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-08-19 | |||||
タイトル | ||||||
タイトル言語 | en | |||||
タイトル | Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti-inflammatory response | |||||
タイトル | ||||||
タイトル言語 | ja | |||||
タイトル | Lactobacillus plantarum 06CC2 の腸炎予防効果の検討 | |||||
著者 |
田中, 啓仁
× 田中, 啓仁 |
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言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | colitis | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | inflammatory bowel disease | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | Lactobacillus | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | microbiota | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | interleukin‑10 | |||||
キーワード | ||||||
主題言語 | en | |||||
主題Scheme | Other | |||||
主題 | Lactobacillus plantarum 06CC2 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
要約(Abstract) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Dysbiosis of the enteric microbiota causes gastrointestinal diseases, including colitis. The present study investigated the beneficial effect of Lactobacillus plantarum 06CC 2 in experimental colitis in mice. An experimental colitis model in C57BL6 mice was induced using dextran sulfate sodium. Mice were orally administered 06CC 2 (06CC 2 group) or PBS only (control group) by gavage. The disease activity index (DAI ), histological grading, and colon tissue and colonic lamina propria mononuclear cells (LPMCs) were examined macroscopically and histopathologically, and the expression levels of inflammation‑associated cytokines (IL‑ 6, IL‑ 12, TNF‑α and IL‑ 10) in these samples were determined. Compared with the control group, the 06CC 2 group exhibited a significantly lower DAI (1.5±0.8 vs. 0.2±0.3, respectively; P<0.05) and pathology score (6.3±1.5 vs. 3.8±1.3, respectively; P<0.05). IL‑ 10 expression in colonic LPMCs was higher in the 06CC 2 group than in the control group, although there was no significant difference in IFN‑γ, IL‑ 6 or IL‑ 12 expression in colonic LPMCs between the two groups. In addition, 06CC 2 stimulated the production of IL‑ 10 from CD 11b‑positive cells and CD 11c‑positive cells in the colon. The 06CC 2 strain induced IL‑ 10 production in the colon and attenuated colon inflammation. AKIHITO TANAKA, SHUJI KANMURA, YUKO MORINAGA, KATSUTO KAWABATA, SHIHO ARIMA, FUMISATO SASAKI, YUICHIROU NASU, SHIROH TANOUE, SHINICHI HASHIMOTO, MASAHIKO TAKESHITA, SHIRO TAKEDA and AKIO IDO Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response Molecular Medicine RE POR TS 21: 1181-1191, 2020 DOI : 10.3892/mmr.2020.10925 |
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内容記述言語 | en | |||||
作成日 | ||||||
日付 | 2020-07-03 | |||||
日付タイプ | Collected | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NDC | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
ファイル(説明) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 | |||||
言語 | ja | |||||
公開者・出版者 | ||||||
出版者言語 | en | |||||
出版者 | Spandidos Publications | |||||
公開者・出版者 | ||||||
出版者言語 | ja | |||||
出版者 | 鹿児島大学 | |||||
公開者・出版者 | ||||||
出版者言語 | ja-Kana | |||||
出版者 | カゴシマ ダイガク | |||||
備考 | ||||||
備考 | 【指導教員:井戸章雄】 | |||||
date.appl | ||||||
【学位申請日】2020-03-04 | ||||||
学位名 | ||||||
学位名の言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位名 | ||||||
学位名の言語 | en | |||||
学位名 | Doctor of Philosophy in Medical Science | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17701 | |||||
学位授与機関名の言語 | ja | |||||
学位授与機関名 | 鹿児島大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2020-07-15 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲総研第565号 |