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Decreased Level of Anxiety-like Behaviors and Decreased Expression of Brain Tryptophan Hydroxylase in Aralar-deficient Mice : A Preliminary Study Aralar欠損マウスにおける脳内トリプトファン水酸化酵素の発現の減少と不安様行動の減少についての予報 MATSUMOTO, Yasuhide 松元, 泰英 SHIMOTSU, Kyoko 下津, 京子 IIJIMA, Mikio 飯島, 幹雄 SAHEKI, Takeyori 佐伯, 武頼 NAKAGAWA, Shiro 中河, 志朗 open access aralar serotonin tryptophan hydroxylase elevated plus-maze test light-dark exploration test Aralar, an isoform of the calcium-binding aspartate-glutamate mitochondrial carrier, is distributed specifically in the brain and skeletal muscles. The aim of the present study was to investigate behaviors induced by the decreased expression of aralar in the brain and to assess whether expression of brain tryptophan hydroxylase, a key enzyme in serotonin synthesis, is correlative with behavioral changes in aralar-deficient mice. In the elevated plus-maze test, heterozygous mice (Aralar^{＋/－}) spent more time in the open arms and showed a significant increase in the number of entries to the open arms compared to wild-type littermates (Aralar^{＋/＋}). In addition, Aralar^{＋/－} mice spent more time in the light compartment in a light-dark exploration test compared to Aralar^{＋/＋} mice. Western blot analysis showed a decreased expression of brain tryptophan hydroxylase in Aralar^{＋/－} mice compared to Aralar^{＋/＋} mice. These results suggested that Aralar^{＋/－} mice exhibit a lower level of anxiety-like behaviors compared to Aralar^{＋/＋} littermates. This might be correlative with the reduced serotonin synthesis. 鹿児島大学 Kagoshima University 2012-01-01 eng departmental bulletin paper VoR http://hdl.handle.net/10232/14463 https://ir.kagoshima-u.ac.jp/records/11064 03685063 AN00040104 鹿児島大学医学雑誌 Medical journal of Kagoshima University 63 3 59 65 https://ir.kagoshima-u.ac.jp/record/11064/files/AN00040104_v63n3_p59-65.pdf application/pdf 235.6 kB 2016-10-31 2012-01-01