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oai:ir.kagoshima-u.ac.jp:00011670 2026-03-03T15:12:01Z 228:230:5171 57:58:59

遺伝子組換え型ヒトトロンボモジュリン製剤とPMX-DHPの併用療法が有効であった大腸癌急性汎発性腹膜炎の２例 Two Cases of Panperitonitis due to Colon Cancer for Which a Therapy with both Human Soluble Thrombomodulin and Polymyxin B-Immobillized Fiber Column-Direct Hemoperfusion was Effective 小川, 信 OGAWA, Shin 出先, 亮介 DESAKI, Ryosuke 金子, 公一 KANEKO, Koichi 保, 清和 TAMOTSU, Kiyokazu 小代, 正隆 OJIRO, Masataka 1000070237577 夏越, 祥次 NATSUGOE, Shoji open access Colorectal Neoplasms Disseminated Intravascular Coagulation DIC Thrombomodulin Polymyxin B-immobilized fiber column-direct hemoperfusion We experienced two cases of panperitonitis due to colon cancer for which a therapy both with human soluble thrombomodulin (rTM) and Polymyxin B-immobilized fiber column-direct hemoperfusion(PMX-DHP) was effective. An 80-year-old woman was referred to our hospital by ileus. Stoma at the transverse colon was made for obstruction of colon by rectal cancer. Intensive care was done for postoperative pre-DIC and ARDS. Sequential Organ Failure Assesment Score (SOFA score) improved from eight to two owing to effect of the combination therapy. Another 82-year-old woman was referred to our hospital as lower intestinal perforation was suspected. Abdominal CT examination revealed sigmoid colon perforation due to rectal cancer. We performed urgently recto-sigmoidectomy and stoma formation of sigmoid colon. Although she suffered from DIC after surgery, SOFA score improved from 11 to 7 by the combination therapy. It was thought that the combination therapy was effective for inflammatory DIC caused by acute panperitonitis by colon cancer. 鹿児島大学 Kagoshima University 2013 jpn departmental bulletin paper VoR http://hdl.handle.net/10232/21160 https://ir.kagoshima-u.ac.jp/records/11670 03685063 AN00040104 鹿児島大学医学雑誌 Medical journal of Kagoshima University 65 1 19 24 https://ir.kagoshima-u.ac.jp/record/11670/files/p19-24_鹿児島大学医学雑誌第65巻第1号.pdf application/pdf 745.8 kB 2016-10-31 2013-05-10