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oai:ir.kagoshima-u.ac.jp:00015807 2026-03-03T15:01:01Z 57:86

Evaluation of the wound healing process in rat skin using a hexanoyl group-modified alkaline-treated gelatin porous film 多孔膜状疎水化ゼラチン接着膜がラット背部創傷治癒過程に与える影響の評価 古閑, 崇 コガ, タカシ Koga, Takashi open access Hexanoyl group-modified alkaline-treated gelatin porous film Collagen sponge Scar contracture Wound healing Dressing material 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 The present study investigated the wound healing process in a rat skin wound model dressed with a hexanoyl group-modified alkaline-treated gelatin porous (HxAlGltn) film with angiogenesis-inducing and strong bioadhesive properties or a collagen sponge (CS). A circular 10-mm full-thickness skin defect was created on the backs of 8-week-old rats and then dressed with a HxAlGltn film (HxAlGltn group), collagen sponge (CS group), and no dressing (control group). Wound distances and areas were assessed macroscopically at specific time points after surgery, the lengths and thicknesses of the neo-epithelium histologically, and α-smooth muscle actin (α-SMA), collagen type I, and fibronectin immunohistochemically. Wound distances and areas were significantly smaller in the HxAlGltn group than in the CS and control groups. The expression of α-SMA in myofibroblasts was significantly weaker in the HxAlGltn group than in the other groups on day 7. Furthermore, angiogenesis was prominent on days 4 and 7 in the HxAlGltn group. No significant differences were observed in the length of the neo-epithelium between all groups, whereas the thickness of the neo-epithelium was greater in the HxAlGltn group than in the CS group. The present results suggest the potential of the HxAlGltn film as a dressing material in the wound healing process of full-thickness skin defects because it reduces scar contraction and promotes angiogenesis more than CS. This is the peer reviewed version of the following article: Takashi Koga, Toshiro Kibe, Tetsushi Taguchi, Takao Fuchigami, Kazuhide Nishihara, Kiyohide Ishihata, Norifumi Nakamura. Evaluation of the wound healing process in rat skin using a hexanoyl group-modified alkaline-treated gelatin porous film Oral Science International (2021), 18(1), 40-49 © 2020 Japanese Stomatological Society which has been published in final form at https://doi.org/10.1002/osi2.1077 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Japanese Stomatological Society 鹿児島大学 eng doctoral thesis VoR http://hdl.handle.net/10232/00031695 https://ir.kagoshima-u.ac.jp/records/15807 甲総研第580号 博士(歯学) Doctor of Philosophy in Dental Science 2021-02-25 17701 鹿児島大学 https://ir.kagoshima-u.ac.jp/record/15807/files/Diss_古閑_崇_4515810053_2020.pdf application/pdf 3.5 MB 2021-09-07 2021-02-09 https://ir.kagoshima-u.ac.jp/record/15807/files/Abstract_古閑_崇_4515810053_2020.pdf application/pdf 210.0 kB 2021-09-07 2021-02-09 https://ir.kagoshima-u.ac.jp/record/15807/files/Result_Koga_Takashi_isk_580.pdf application/pdf 217.9 kB 2021-04-09 2021-02-09 https://ir.kagoshima-u.ac.jp/record/15807/files/Comments_Koga_Takashi_isk_580.pdf application/pdf 110.0 kB 2021-04-09 2021-02-09