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oai:ir.kagoshima-u.ac.jp:00004306 2026-03-03T15:12:06Z 228:230:5158 57:58:59

Prognostic Factors of 10-Year Survivors after Initial Treatmentfor Hepatocellular Carcinoma, Determined in 713 Japanese Patientsin Relation to Indication of Liver Transplantation. TATENO, Taro UENO, Shinichi SAKODA, Masahiko KUBO, Fumitake HIWATASHI, Kiyokazu BABA, Yoshiro BABA, Yasutaka HASEGAWA, Susumu TSUBOUCHI, Hirohito NATSUGOE, Shoji open access Milan criteria, Child-Pugh stage hepatitis C virus infection hepatectomy Purpose: To clarify the prognostic factors for long-term survival by studying the clinical factors of 10-year survivors after initial treatment for hepatocellular carcinoma (HCC). Methods: 713 Japanese patients who had received over 10 year’s observation after initial treatment for HCC were selected. Differences in clinical factors between 10-year survivors and the remainder were studied. The multiple logistic regression model was used for multivariate analysis. Results: Significant differences were noted between the groups in age, tumor number, vascular involvement, concordance of Milan Criteria (MC), Japanese tumor-node-metastasis stage, Child-Pugh stage (CP), HCV infection, serum α-fetoprotein level, and modality of initial treatment. Multivariate analysis showed that older age, out of MC, CP-B or -C, and initially treated other than by hepatectomy were independent risk factors for 10-year survival. If patients were within MC and CP-A, the overall 10-year survival rate of those initially treated by hepatectomy was 71%, and 49% for those with HCV infection. Conclusions: Younger patients with initial HCC within MC and CP-A can expect long-term survival, if surgically resectable. Hepatectomy should be considered especially to HCC patients with HCV infection, if in these categories. 鹿児島大学 Kagoshima University 2008 eng departmental bulletin paper VoR http://hdl.handle.net/10232/8586 https://ir.kagoshima-u.ac.jp/records/4306 03685063 AN00040104 鹿児島大学医学雑誌 Medical journal of Kagoshima University 60 2 45 54 https://ir.kagoshima-u.ac.jp/record/4306/files/60(2)_1_T.pdf application/pdf 289.8 kB 2016-10-27 2008-09-01