2026-03-12T22:09:56Z https://ir.kagoshima-u.ac.jp/oai

oai:ir.kagoshima-u.ac.jp:00015245 2026-03-03T15:00:53Z 57:86

Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti-inflammatory response Lactobacillus plantarum 06CC2 の腸炎予防効果の検討 田中, 啓仁 タナカ, アキヒト Tanaka, Akihito open access colitis inflammatory bowel disease Lactobacillus microbiota interleukin‑10 Lactobacillus plantarum 06CC2 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 Dysbiosis of the enteric microbiota causes gastrointestinal diseases, including colitis. The present study investigated the beneficial effect of Lactobacillus plantarum 06CC 2 in experimental colitis in mice. An experimental colitis model in C57BL6 mice was induced using dextran sulfate sodium. Mice were orally administered 06CC 2 (06CC 2 group) or PBS only (control group) by gavage. The disease activity index (DAI ), histological grading, and colon tissue and colonic lamina propria mononuclear cells (LPMCs) were examined macroscopically and histopathologically, and the expression levels of inflammation‑associated cytokines (IL‑ 6, IL‑ 12, TNF‑α and IL‑ 10) in these samples were determined. Compared with the control group, the 06CC 2 group exhibited a significantly lower DAI (1.5±0.8 vs. 0.2±0.3, respectively; P<0.05) and pathology score (6.3±1.5 vs. 3.8±1.3, respectively; P<0.05). IL‑ 10 expression in colonic LPMCs was higher in the 06CC 2 group than in the control group, although there was no significant difference in IFN‑γ, IL‑ 6 or IL‑ 12 expression in colonic LPMCs between the two groups. In addition, 06CC 2 stimulated the production of IL‑ 10 from CD 11b‑positive cells and CD 11c‑positive cells in the colon. The 06CC 2 strain induced IL‑ 10 production in the colon and attenuated colon inflammation. AKIHITO TANAKA, SHUJI KANMURA, YUKO MORINAGA, KATSUTO KAWABATA, SHIHO ARIMA, FUMISATO SASAKI, YUICHIROU NASU, SHIROH TANOUE, SHINICHI HASHIMOTO, MASAHIKO TAKESHITA, SHIRO TAKEDA and AKIO IDO Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response Molecular Medicine RE POR TS 21: 1181-1191, 2020 DOI : 10.3892/mmr.2020.10925 Spandidos Publications 鹿児島大学 eng doctoral thesis VoR http://hdl.handle.net/10232/00031139 https://ir.kagoshima-u.ac.jp/records/15245 甲総研第565号 博士(医学) Doctor of Philosophy in Medical Science 2020-07-15 17701 鹿児島大学 https://ir.kagoshima-u.ac.jp/record/15245/files/Diss_田中_啓仁_ISK565_2020.pdf application/pdf 1.4 MB 2021-05-19 2020-07-03 https://ir.kagoshima-u.ac.jp/record/15245/files/Abstract_田中_啓仁_4509800196_2019.pdf application/pdf 162.1 kB 2021-05-06 2020-07-03 https://ir.kagoshima-u.ac.jp/record/15245/files/Result_Tanaka_Akihito_isk_565.pdf application/pdf 1.2 MB 2020-08-19 2020-07-03 https://ir.kagoshima-u.ac.jp/record/15245/files/Comments_Tanaka_Akihito_isk_565.pdf application/pdf 439.8 kB 2020-08-19 2020-07-03