2026-03-06T11:43:35Z https://ir.kagoshima-u.ac.jp/oai

oai:ir.kagoshima-u.ac.jp:00016555 2026-03-03T14:50:56Z 168:169

Associations of the alpha-actinin three genotype with bone and muscle mass loss among middle-aged and older adults 中高齢者におけるα-アクチニン3遺伝子多型と骨量および筋量低下との関連性 谷口, 善昭 タニグチ, ヨシアキ Taniguchi, Yoshiaki open access ACTN3 gene osteoporosis sarcopenia osteosarcopenia 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨 Bone and muscle mass loss are known to occur simultaneously. The alpha-actinin three (ACTN3) genotype has been shown to potentially affect bone and muscle mass. In this study, we investigated the association between the ACTN3 genotype and bone and muscle mass loss in community-dwelling adults aged ≥ 60 years. This study was a cross-sectional analysis of data from 295 participants who participated in a community health checkup. The ACTN3 genotypes were classified as RR, RX, or XX types. Bone mass loss was defined as a calcaneal speed of sound T-score of <−1.32 and <−1.37, and muscle mass loss was defined as an appendicular skeletal muscle index of <7.0 kg/m2 and <5.7 kg/m2 in men and women, respectively. The percentages of XX, RX, and RR in the combined bone and muscle mass loss group were 33.8%, 30.8%, and 16.7%, respectively, with a significantly higher trend for XX. Multinomial logistic regression analysis showed that XX had an odds ratio of 3.00 (95% confidence interval 1.05–8.54) of being in the combined bone and muscle mass loss group compared to the RR group (covariates: age, sex, grip strength, and medications). The ACTN3 genotype of XX is associated with a higher rate of comorbid bone and muscle mass loss. Therefore, ACTN3 genotyping should be considered for preventing combined bone and muscle mass loss. Yoshiaki Taniguchi, Hyuma Makizako, Yuki Nakai, Yuto Kiuchi, Shoma Akaida, Mana Tateishi, Toshihiko Takenaka, Takuro Kubozono and Mitsuru Ohishi Associations of the Alpha-Actinin Three Genotype with Bone and Muscle Mass Loss among Middle-Aged and Older Adults Journal of Clinical Medicine 2022, 11, 6172 https://doi.org/10.3390/jcm11206172 MDPI 鹿児島大学 eng doctoral thesis VoR http://hdl.handle.net/10232/00032439 https://ir.kagoshima-u.ac.jp/records/16555 甲保研第34号 博士（保健学） Doctor of Philosophy in Health Science 2023-03-23 17701 鹿児島大学 https://ir.kagoshima-u.ac.jp/record/16555/files/Diss_谷口善昭_HOK034_2022.pdf application/pdf 389.4 kB 2023-03-15 2023-03-13 https://ir.kagoshima-u.ac.jp/record/16555/files/Abstract_谷口善昭_4720700058_2022.pdf application/pdf 145.9 kB 2023-03-15 2023-03-13 https://ir.kagoshima-u.ac.jp/record/16555/files/Result_TANIGUCHI_Yoshiaki_hok_34.pdf application/pdf 121.7 kB 2023-04-20 2023-03-13 https://ir.kagoshima-u.ac.jp/record/16555/files/Comments_TANIGUCHI_Yoshiaki_hok_34.pdf application/pdf 64.5 kB 2023-04-20 2023-03-13