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Metachronous occurrence of gastric T-cell rich B-cell lymphoma and nodal T-cell lymphoma in a HTLV-1 carrier Hasui, Kazuhisa 117095 Shirahama, Hiroshi 117096 Sueyoshi, Kazunobu 117097 Sato, Eiichi 117098 Imakuma, Mitsuru 117099 490 医学 HTLV-1 malignant lymphoma pathology histochemistry polymerase chain reaction ln a HTLV-1 carrier Japanese man gastric T cell-rich B cell lymphoma occurred at 67 years of age and nodal T cell malignant lymphoma appeared at 72 years of age. The gastric T-cell rich B-cell Iymphoma formed an ulcerated tumor in the posterior wall of the body, involving up to the serosa and regional lymph nodes. A few lymphoma cells had cytoplasmic monoclonal κ and λ type immunoglobulin. Signals of HTLV-l pX Tax DNA sequence and stains of three antibodies against HTLV-1-encoded proteins (gp46env, p40tax and p19gag) in some lymphoma cells suggested that this gastric lymphoma was a HTLV-1-related case. Six years later, large cell type T-cell malignant lymphoma occurred in left inguinal lymph node. Many S100+ dendritic cells and ysozyme+ cells were intermingling among the lymphoma cells. Some epithelioid cells among the lymphoma cells showed weak stains of the three antibodies against HTLV-l-encoded proteins. The PCR analysis showed oligoclonal rearrangement bands of TCRβ gene in the agar-gel electrophoresis. After three months' follow-up without chemotherapy, recurrent swelling of left inguinal lymph node and splenomegaly appeared. After chemotherapy the biopsied left inguinal lymph node showed necrosis and residual T cell malignant lymphoma. The uncommon features such as many T cells in the gastric lymphoma and many S100+ cells, many lysozyme+ cells and oligoclonal rearrangement of TCRβ gene in the nodal T-cell lymphoma might be induced by HTLV-1 infection. The patient has survived without any complaints. The HTLV-l-related lymphoid malignancies other than adult T-cell leukemia/lymphoma would be not-aggressive and might be the diseases in the microenvironment under the immunocompromised state in HTLV-1 carrier. journal article 日本樹状細胞研究会 Japanese Dendritic Cells Society 1996-01-01 AM application/pdf Dendritic cells 6 14 21 AA11039557 https://ir.kagoshima-u.ac.jp/record/6796/files/DC(Hasui)1996.pdf http://hdl.handle.net/10232/3740 https://ir.kagoshima-u.ac.jp/records/6796 eng open access