{"created":"2023-07-25T08:03:07.457032+00:00","id":1027,"links":{},"metadata":{"_buckets":{"deposit":"26319eec-cd88-456c-a3b1-32d0a6da5fe9"},"_deposit":{"created_by":18,"id":"1027","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"1027"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00001027","sets":["82:83"]},"author_link":["6511"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2012年度科学研究費助成事業(科学研究費補助金(若手研究(B))研究成果報告書　課題番号：23791911　研究代表者：宮下圭一(鹿児島大学・医学部・歯学部附属病院・助教)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"マウスのアレルギー性鼻炎モデルを用いて、Th1/Th2バランスおよびアレルギー病態に対するPCの関与について検討した。OVA感作前にPC-BSAを経鼻投与し、アレルギー症状、鼻粘膜への好酸球浸潤、血清IgE値、脾臓のCD4陽性T細胞のサイトカイン産生能を検討した。PC-BSAの経鼻前投与によりくしゃみ、鼻掻き回数が減少し、血清中OVA特異的IgE濃度の低下を認めた。さらに脾臓CD4陽性T細胞のIL-4産生の減少が認められた。これらの結果からマウスのPC前投与のアレルギー性鼻炎に対する抑制効果が示唆され、PCにはTh2型のアレルギー反応を抑制する働きがあると考えられた。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Background: Phosphorylcholine (PC), which is a structural component of wide variety of bacteria. However immunomodulatory properties of PC in the upper respiratory tract have not yet been characterized. Objective: We sought to elucidate the effects of PC on the regulation of allergic response in the upper respiratory tract. Methods: Allergic rhinitis model established by ovalbumin (OVA) sensitization was pretreated by intranasal or peritoneal administration of PC-bovine serum albumin (PC-BSA). Allergic responses were compared with non-pretreated mice. IL-12p40 production by DCs stimulated with PC was measured to evaluate the effect of PC on the TH2 responses mediated by DCs. Results: PC-pretreated mice showed mild allergic nasal symptoms compared to the mice without PC-pretreatment. The levels of total IgE and OVA-specific IgE were significantly lower in PC-pretreated mice. The IL-4 production by splenic CD4+ T cells was down-regulated by PC-pretreatment. Further, PC induced IL-12p40 production by DCs. Conclusion: These findings indicate that PC inhibits the allergic response in the upper respiratory tract mediated by the induction of IL-12p40 production by DCs. Thus, PC might be useful as an immunotherapeutic agent for allergic diseases.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"496","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23791911"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮下, 圭一","creatorNameLang":"ja"},{"creatorName":"MIYASHITA, Kiichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6511","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000030585063","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"23791911.pdf","filesize":[{"value":"575.5 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23791911.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/1027/files/23791911.pdf"},"version_id":"1dad0cee-4b1e-4e8c-a813-975acfe20946"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"粘膜ワクチン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Th1/Th2 バランス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Phosphprylcholine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"アレルギー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"粘膜ワクチンによるⅠ型アレルギーの誘導機序とその制御に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"粘膜ワクチンによるⅠ型アレルギーの誘導機序とその制御に関する研究","subitem_title_language":"ja"},{"subitem_title":"Phosphorylcholine Suppresses the Allergic Rhinitis in Mice","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["83"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-10-01"},"publish_date":"2013-10-01","publish_status":"0","recid":"1027","relation_version_is_last":true,"title":["粘膜ワクチンによるⅠ型アレルギーの誘導機序とその制御に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-10T05:23:28.214484+00:00"}