{"created":"2023-07-25T08:03:07.589043+00:00","id":1030,"links":{},"metadata":{"_buckets":{"deposit":"3bd91ee4-946d-442a-bf59-9f42e89406a3"},"_deposit":{"created_by":18,"id":"1030","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"1030"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00001030","sets":["57:78"]},"author_link":["116754","116755","116756","116757","116758","116759","116760","116761"],"item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1442","bibliographicPageStart":"1337","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Oncology Reports","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-08-05","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"GOLPH3 was originally identified by proteomic analyses of Golgi proteins localized in the trans-Golgi network. Recently, it was reported that GOLPH3 is up-regulated in various types of malignancies, including melanoma, colon cancer and lung cancer. However, the mechanism through which GOLPH3 is involved in the pathogenesis of rhabdomyosarcoma remains unidentified. In order to explore the function of GOLPH3 and its isoform, GOLPH3L, in the pathogenesis of rhabdomyosarcoma, we investigated the expression and knockdown effects of GOLPH3 and GOLPH3L in human rhabdomyosarcoma. Western blot analysis and real-time PCR revealed that human rhabdomyosarcoma cell lines and biopsy specimens exhibited an increased expression of GOLPH3 and GOLPH3L. GOLPH3 and GOLPH3L knockdown by siRNA prevented the proliferation of human rhabdomyosarcoma cell lines. In addition, double-knockdown of GOLPH3 and GOLPH3L also prevented the proliferation of rhabdomyosarcoma cell lines. Our findings improve the understanding of rhabdomyosarcoma pathogenesis and suggest that the knockdown of GOLPH3 or GOLPH3L may be an effective treatment for rhabdomyosarcoma.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications","subitem_publisher_language":"en"}]},"item_6_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3892/or.2011.1413","subitem_relation_type_select":"DOI"}}]},"item_6_relation_32":{"attribute_name":"関連（relation）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.spandidos-publications.com/or/26/5/1337?text=abstract","subitem_relation_type_select":"URI"}}]},"item_6_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Spandidos Publications","subitem_rights_language":"en"}]},"item_6_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1021335X","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11016405","subitem_source_identifier_type":"NCID"}]},"item_6_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494.5","subitem_subject_scheme":"NDC"}]},"item_6_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kunigou, Osamu","creatorNameLang":"en"},{"creatorName":"クニゴウ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"救仁郷, 修","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagao, Hiroko","creatorNameLang":"en"},{"creatorName":"ナガオ, ヒロコ","creatorNameLang":"ja-Kana"},{"creatorName":"永尾, 宗子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawabata, Naoya","creatorNameLang":"en"},{"creatorName":"カワバタ, ナオヤ","creatorNameLang":"ja-Kana"},{"creatorName":"川畑, 直也","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishidou, Yasuhiro","creatorNameLang":"en"},{"creatorName":"イシドウ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"石堂, 康弘","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagano, Satoshi","creatorNameLang":"en"},{"creatorName":"ナガノ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"永野, 聡","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Shingo","creatorNameLang":"en"},{"creatorName":"マエダ, シンゴ","creatorNameLang":"ja-Kana"},{"creatorName":"前田, 真吾","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komiya, Setsuro","creatorNameLang":"en"},{"creatorName":"コミヤ, セツロウ","creatorNameLang":"ja-Kana"},{"creatorName":"小宮, 節郎","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Setoguchi, Takao","creatorNameLang":"en"},{"creatorName":"セトグチ, タカオ","creatorNameLang":"ja-Kana"},{"creatorName":"瀬戸口, 啓夫","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma.pdf","filesize":[{"value":"499.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/1030/files/Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma.pdf"},"version_id":"61553296-cef3-4c8f-8c19-6b185cb6bec8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"rhabdomyosarcoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GOLPH3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GOLPH3L","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell proliferation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Golgi apparatus","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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