@article{oai:ir.kagoshima-u.ac.jp:00001036,
 author = {Jayalekshmi, Padmavathy Amma and Nandakumar, Athira and Akiba, Suminori and 秋葉, 澄伯 and Gangadharan, Paleth and Koriyama, Chihaya and 郡山, 千早},
 issue = {8},
 journal = {PLOS ONE},
 month = {},
 note = {Background: From among a cohort of 65,553 men aged 30-84 in Karunagappally Taluk, Kerala, India, 52 hypopharyngeal cancer cases and 85 laryngeal cancer cases were identified by the Karunagappally Cancer Registry during the period between 1990 and 2009. Methods: We conduct Poisson regression analysis of grouped data, taking into account age and education. Results: This study showed that the incidence rates of cancer soft heh ypopharynxand the IarynxwerestrongIy related to the number of bidis smoked a day(P<0.001 for both hypopharyngeal and Iaryngeal cancers) and duration of bidi smoking(P=0.009; <0.001). Laryngeal cancer risk was significantly increased by bidi smoking (P<0.001), cigarette smoking (P=0.013) and regular alcohol use (P=0.005). Conclusion: The present study, the first cohort study to examine the association of hypopharyngeal and laryngeal cancer incidence rates with bidi smoking in South Asia, clearly showed dose-response relationships between those cancer risks and bidi smoking; larger amounts of bidi smoked a day and longer durations of bidi smoking increased the incidence rates of those cancers. Tobacco chewing was found not related to the risk of hypopharynx or larynx cancer.},
 title = {Associations of Tobacco Use and Alcohol Drinking with Laryngeal and Hypopharyngeal Cancer Risks among Men in Karunagappally, Kerala, India -Karunagappally Cohort Study},
 volume = {8},
 year = {2013}
}