{"created":"2023-07-25T08:10:40.027123+00:00","id":10643,"links":{},"metadata":{"_buckets":{"deposit":"dfe48bc0-177e-4a46-abed-64af24757d4b"},"_deposit":{"created_by":18,"id":"10643","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"10643"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00010643","sets":["82:83"]},"author_link":["50372"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-06-02","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2008-2010年度科学研究費補助金(若手研究(B))研究成果報告書 課題番号：20791619　研究代表者：中島結実子 (鹿児島大学医学部・歯学部附属病院医員)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"本研究では、肥満の誘発性因子や炎症メディエーターである内因性カンナビノイド（アナンダマイド（AEA）、2-AG）を、動脈硬化性疾患と歯周病の関連性を評価する指標として着眼した。歯肉溝内のAEA、2-AGと、血中総コレステロール、トリグリセライド、AEA、2-AGと歯周病態との関連を検討した。いずれの項目においても歯周病態との有意な関連性は認められなかったが、歯周病態の悪化によりこれらの増加傾向を認めた。特に心疾患罹患患者では、その傾向が強かった。以上より歯周病において、歯周組織局所(歯肉溝)で内因性カンナビノイドが産生され、血流を介して全身の脂質代謝に影響を及ぼしていることが考えられる。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"In this study, we focus on endocannainoid (anandamide(AEA), 2-AG) for an indicator of estimation of the relationship between Arteriosclerotic disease and Periodontal disease. We investigated the relationship between periodontal progression and AEA and 2-AG in periodontal pocket and total cholesterol, triglyceride, AEA and 2-AG inperipheral blood. None of significant relationship observed between periodontal progression and all of them. But they tend to increase proportionally with periodontal disease progression, especially in patient with heart disease. These results suggested that endocannabinoid are produced in periodontal pocket and these cannaibnoid affect systemic metabolism via blood flow.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"20791619"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中島, 結実子","creatorNameLang":"ja"},{"creatorName":"NAKAJIMA, Yumiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"50372","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040433081","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"20791619seika.pdf","filesize":[{"value":"231.1 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"20791619seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/10643/files/20791619seika.pdf"},"version_id":"0030ae76-bccb-43a5-8a82-fcf30085044f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"歯周病","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"内因性カンナビノイド","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"内因性カンナビノイドを介する歯周病と動脈硬化性疾患の関連性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"内因性カンナビノイドを介する歯周病と動脈硬化性疾患の関連性","subitem_title_language":"ja"},{"subitem_title":"The relationship between Arteriosclerotic disease and Periodontal disease via endocannabinoid","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["83"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"10643","relation_version_is_last":true,"title":["内因性カンナビノイドを介する歯周病と動脈硬化性疾患の関連性"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-10T05:23:22.919110+00:00"}