{"created":"2023-07-25T08:10:41.193810+00:00","id":10670,"links":{},"metadata":{"_buckets":{"deposit":"780e4b0f-9c6d-4463-8764-442f9633b037"},"_deposit":{"created_by":29,"id":"10670","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"10670"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00010670","sets":["57:80"]},"author_link":["50497"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2008-2010年度科学研究費補助金(基盤研究(B))研究成果報告書 課題番号：20390427　研究代表者：中川昌之 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"我々は臨床尿路上皮癌において667種類microRNAスクリーニングを行い、構築したプロファイルに基づいて、癌抑制的microRNA（miR-1, miR-218, miR-133a, miR-145, miR-517a）の同定とそれらの標的遺伝子(FSCN1, LASP1, TAGLN2, GSTP1)の機能解析を行った。また発現が上昇していたmiR-96, miR-183の尿中マーカーとしての有用性を検討した。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"We screened 667 microRNAs in urothelial carcinoma specimens and identified the profile of down-regulated miRNAs, such as miR-1, miR-133a, and miR-145, which have tumor suppressive function. These miRNAs directly repressed the expression levels of novel oncogenic genes, such as FSCN1, LASP1, and GSTP1. On the other hand, miR-96 and miR-183, which were the top two up-regulated miRNAs in the profile, were subjected to tests for evaluating their ability as urine markers.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"20390427"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中川, 昌之","creatorNameLang":"ja"},{"creatorName":"NAKAGAWA, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"50497","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090164144","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2011-05-31"}],"filename":"20390427seika.pdf","filesize":[{"value":"305.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"20390427seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/10670/files/20390427seika.pdf"},"version_id":"58b476f4-7d83-4c38-832d-88e5bf7e8397"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"マイクロRNA","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"尿路上皮癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍マーカー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マイクロRNA発現制御による尿路上皮癌の新規治療の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マイクロRNA発現制御による尿路上皮癌の新規治療の開発","subitem_title_language":"ja"},{"subitem_title":"Developing new treatment modalities of urothelial carcinoma through regulating microRNA expression","subitem_title_language":"en"}]},"item_type_id":"8","owner":"29","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"10670","relation_version_is_last":true,"title":["マイクロRNA発現制御による尿路上皮癌の新規治療の開発"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-08-04T07:59:00.763657+00:00"}