@techreport{oai:ir.kagoshima-u.ac.jp:00010672,
 author = {折原, 弘治},
 month = {2016-10-28},
 note = {2008-2010年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号：20590831　研究代表者：折原弘治 (鹿児島大学大学院医歯学総合研究科特任助教), TLR 2(トール様レセプター2) 高値が、周知の危険因子（喫煙習慣、糖尿病、高血圧、高脂血症）とは独立して、動脈硬化形成の一つのリスクファクターとみなすことができるか否かの検討を行った。結果、動脈硬化性疾患群では、単球膜上TLR2レベルは、そのコントロール群に比べて、有意に高かった。更なる解析の結果、TLR2レベルはその他の危険因子とは独立しており、新たな動脈硬化危険因子の一つであることが示唆された。, Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns to initiate an innate immune response. We previously reported upregulation of TLR2 expression level on monocytes of stable angina pectoris patients with significant coronary artery disease (CAD) relative to control patients without significant CAD. In this study we aimed to determine whether high level of Toll-like receptor 2 (TLR2) is a risk factor for atherogenesis, independent of established risk factors including smoking, diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL).TLR2 expression level on circulating monocyte surfaces was measured by using our developed flow cytometry assay. Patients were classified into two roups: "Arteriosclerotic disease" group (n=108) and "Control" group (n=70). Patients of the first group had arteriosclerotic disease such as CAD, aortic aneurysm, or peripheral arterial disease (PAD). The "Control" group was sex- and age-matched to the "Arteriosclerotic disease" group. The results demonstrated that TLR2 expression was significantly higher in the "Arteriosclerotic disease" group than in the "Control" group (p<0.001). Multivariate ordinal logistic regression analysis was performed; other known risk factors, which were represented to two nominal score points, 0 or 1, for patients with and without it, respectively, and TLR2 level, which was treated as a metric variable. DM (p=0.002), HT (p=0.001), HL (p<0.001), and TLR2 level (p<0.001) were identified as significant contributors for arteriosclerotic disease. In conclusion, high TLR2 expression level on monocytes may be an independent risk factor for atherogenesis.},
 title = {動脈硬化疾患における単球膜上トールライクレセプター発現量の検討},
 year = {}
}