{"created":"2023-07-25T08:10:41.328419+00:00","id":10673,"links":{},"metadata":{"_buckets":{"deposit":"74714e90-e249-4b05-ae98-0a4f94e0d541"},"_deposit":{"created_by":18,"id":"10673","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"10673"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00010673","sets":["57:80"]},"author_link":["50505"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2008-2010年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号：20591860　研究代表者：榎田英樹 (鹿児島大学大学院医歯学総合研究科講師)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"我々は前立腺癌でメチル化による発現抑制が見られる遺伝子をリストアップしその中でAPC、GSTP1、MT1Gに注目して、組織検体や尿検体からＤＮＡを抽出しメチル化特異的ＰＣＲ法で各遺伝子のプロモーター領域のメチル化を測定した。その結果、MT1Gメチル化は病理学的ステージと有意に相関した。これらのマーカーは前立腺癌と良性の前立腺肥大症を区別し、診断マーカーやステージングマーカーとして有用である可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"We screened methylated DNA by using oligomicroarray analyses of prostate cancer cell lines treated by a demethylating agent and focused on APC, GSTP1, and MT1G. Prostate tissues and urine samples were used for extracting their DNA, which were subjected to methylation specific PCR. The methylation status of MT1G was significantly associated with tumor stage. These markers may have potential abilities to distinguish prostate cancer from benign prostate hypertrophy.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"20591860"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"榎田, 英樹","creatorNameLang":"ja"},{"creatorName":"ENOKIDA, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"50505","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000080347103","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-28"}],"displaytype":"detail","filename":"20591860seika.pdf","filesize":[{"value":"396.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"20591860seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/10673/files/20591860seika.pdf"},"version_id":"05002ae5-1e69-4cf6-82cb-f4b2ab588546"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"前立腺癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"尿","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"メチル化","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"診断","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"尿中メチル化DNA測定による新しい前立腺癌診断キットの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"尿中メチル化DNA測定による新しい前立腺癌診断キットの開発","subitem_title_language":"ja"},{"subitem_title":"Developing new diagnostic kit for prostate cancer through detecting methylated DNA in urine sample","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"10673","relation_version_is_last":true,"title":["尿中メチル化DNA測定による新しい前立腺癌診断キットの開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:09.139433+00:00"}