{"created":"2023-07-25T08:10:44.753235+00:00","id":10750,"links":{},"metadata":{"_buckets":{"deposit":"890614d4-644d-4954-b220-48c96203b3eb"},"_deposit":{"created_by":3,"id":"10750","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"10750"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00010750","sets":["57:86"]},"author_link":["124934"],"control_number":"10750","item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"351","bibliographicPageStart":"345","bibliographicVolumeNumber":"420","bibliographic_titles":[{"bibliographic_title":"Virchows Archiv. A, Pathological anatomy and histopathology","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"1992-03-31","subitem_date_issued_type":"Issued"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"1992-03-31"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"In this investigation, 83 human mammary carcinomas were examined for the expression of oestrogen receptor (ER), epidermal growth factor receptor (EGF-R), epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), c-erbB-2, histological grade, mitotic index and nodal status, all of which are reportedly prognostically significant factors (Bloom and Richardson 1957; Baak et al. 1985; Wright et al. 1989). ER expression was biochemically recognized in 43.4% of mammary carcinomas, and EGF-R, EGF, TGF-alpha and c-erbB-2 were histochemically recognized in 25.3, 14.5, 27.7 and 18.0% of mammary carcinomas examined respectively, using conventional sections of buffered formalin-fixed, paraffin-embedded tissue and monoclonal or polyclonal antibodies. There were significant relationships between negative ER and positive EGF-R or TGF-alpha; positive EGF-R and TGF-alpha; positive EGF-R and c-erbB-2; and positive c-erbB-2 and TGF-alpha. The single changes which were the negative ER and the positive c-erbB-2 correlated with histological grade and mitotic index. Co-expression of EGF-R and TGF-alpha correlated with positive nodal status. Therefore, the present investigation indicates that the negative ER, single expression of c-erbB-2 and co-expression of EGF-R and TGF-alpha are important markers which contribute indirectly to prognosis, which reconfirms previous findings on the former two while adding the new finding that immunohistochemical demonstration of expression of EGF-R and TGF-alpha may provide useful information for selecting the appropriate treatment.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"医歯学総合研究科博士論文(医学) ; 学位取得日: 平成4年3月31日","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.11501/3060962","subitem_identifier_reg_type":"JaLC"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_5_relation_10":{"attribute_name":"PubMed Id","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"1348890","subitem_relation_type_select":"PMID"}}]},"item_5_relation_32":{"attribute_name":"関連（relation）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://id.ndl.go.jp/bib/000000250014","subitem_relation_type_select":"URI"}}]},"item_5_relation_33":{"attribute_name":"関連（isVersionOf）","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dl.ndl.go.jp/info:ndljp/pid/3060962","subitem_relation_type_select":"URI"}}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0174-7398","subitem_source_identifier_type":"PISSN"}]},"item_5_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA10643181","subitem_source_identifier_type":"NCID"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"平成22年度に行われた国立国会図書館の学位論文（博士）デジタル化事業に際し、著者から、学位授与大学において、国立国会図書館から譲渡を受けた学位論文のデジタル化複製物を利用（全文複写提供、公衆送信）に供することの許諾を受けたものです（参考：http://www.ndl.go.jp/jp/aboutus/digitization_theses.html）。"}]},"item_5_text_52":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"医研第271号"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"梅北, 善久","creatorNameLang":"ja"},{"creatorName":"ウメキタ, ヨシヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Umekita, Yoshihisa","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"000000250014.pdf","filesize":[{"value":"4.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"000000250014.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/10750/files/000000250014.pdf"},"version_id":"8f75e889-62d7-484c-9037-760da004db08"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Breast Cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epidermal growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"EGF receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Transforming growth factor-α","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"c-erbB-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Immunohistochemical studies on oncogene products (EGF-R, c-erbB-2) and growth factors (EGF, TGF-α) in human breast cancer: their relationship to oestrogen receptor status, histological grade, mitotic index and nodal status","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemical studies on oncogene products (EGF-R, c-erbB-2) and growth factors (EGF, TGF-α) in human breast cancer: their relationship to oestrogen receptor status, histological grade, mitotic index and nodal status","subitem_title_language":"en"},{"subitem_title":"ヒト乳癌における癌遺伝子産物〔EGF-R, c-erbB-2〕及び成長因子〔EGF, TGF-α〕発現に関する免疫組織化学的研究 : エストロゲンレセプター, 組織異型度, 核分裂指数及びリンパ節転移との関連について","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-05-17"},"publish_date":"2012-05-17","publish_status":"0","recid":"10750","relation_version_is_last":true,"title":["Immunohistochemical studies on oncogene products (EGF-R, c-erbB-2) and growth factors (EGF, TGF-α) in human breast cancer: their relationship to oestrogen receptor status, histological grade, mitotic index and nodal status"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-12T00:28:27.986946+00:00"}