{"created":"2023-07-25T08:10:44.753235+00:00","id":10750,"links":{},"metadata":{"_buckets":{"deposit":"890614d4-644d-4954-b220-48c96203b3eb"},"_deposit":{"created_by":3,"id":"10750","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"10750"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00010750","sets":["57:86"]},"author_link":["124934"],"control_number":"10750","item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"351","bibliographicPageStart":"345","bibliographicVolumeNumber":"420","bibliographic_titles":[{"bibliographic_title":"Virchows Archiv. A, Pathological anatomy and histopathology","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"1992-03-31","subitem_date_issued_type":"Issued"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"1992-03-31"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"In this investigation, 83 human mammary carcinomas were examined for the expression of oestrogen receptor (ER), epidermal growth factor receptor (EGF-R), epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), c-erbB-2, histological grade, mitotic index and nodal status, all of which are reportedly prognostically significant factors (Bloom and Richardson 1957; Baak et al. 1985; Wright et al. 1989). ER expression was biochemically recognized in 43.4% of mammary carcinomas, and EGF-R, EGF, TGF-alpha and c-erbB-2 were histochemically recognized in 25.3, 14.5, 27.7 and 18.0% of mammary carcinomas examined respectively, using conventional sections of buffered formalin-fixed, paraffin-embedded tissue and monoclonal or polyclonal antibodies. There were significant relationships between negative ER and positive EGF-R or TGF-alpha; positive EGF-R and TGF-alpha; positive EGF-R and c-erbB-2; and positive c-erbB-2 and TGF-alpha. The single changes which were the negative ER and the positive c-erbB-2 correlated with histological grade and mitotic index. Co-expression of EGF-R and TGF-alpha correlated with positive nodal status. Therefore, the present investigation indicates that the negative ER, single expression of c-erbB-2 and co-expression of EGF-R and TGF-alpha are important markers which contribute indirectly to prognosis, which reconfirms previous findings on the former two while adding the new finding that immunohistochemical demonstration of expression of EGF-R and TGF-alpha may provide useful information for selecting the appropriate treatment.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"医歯学総合研究科博士論文(医学) ; 学位取得日: 平成4年3月31日","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.11501/3060962","subitem_identifier_reg_type":"JaLC"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_5_relation_10":{"attribute_name":"PubMed 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善久","creatorNameLang":"ja"},{"creatorName":"ウメキタ, ヨシヒサ","creatorNameLang":"ja-Kana"},{"creatorName":"Umekita, Yoshihisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"124934","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"000000250014.pdf","filesize":[{"value":"4.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"000000250014.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/10750/files/000000250014.pdf"},"version_id":"8f75e889-62d7-484c-9037-760da004db08"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Breast Cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epidermal growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"EGF receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Transforming growth factor-α","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"c-erbB-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Immunohistochemical studies on oncogene products (EGF-R, c-erbB-2) and growth factors (EGF, TGF-α) in human breast cancer: their relationship to oestrogen receptor status, histological grade, mitotic index and nodal status","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemical studies on oncogene products (EGF-R, c-erbB-2) and growth factors (EGF, TGF-α) in human breast cancer: their relationship to oestrogen receptor status, histological grade, mitotic index and nodal status","subitem_title_language":"en"},{"subitem_title":"ヒト乳癌における癌遺伝子産物〔EGF-R, c-erbB-2〕及び成長因子〔EGF, TGF-α〕発現に関する免疫組織化学的研究 : エストロゲンレセプター, 組織異型度, 核分裂指数及びリンパ節転移との関連について","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-05-17"},"publish_date":"2012-05-17","publish_status":"0","recid":"10750","relation_version_is_last":true,"title":["Immunohistochemical studies on oncogene products (EGF-R, c-erbB-2) and growth factors (EGF, TGF-α) in human breast cancer: their relationship to oestrogen receptor status, histological grade, mitotic index and nodal status"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-12T00:28:27.986946+00:00"}