@article{oai:ir.kagoshima-u.ac.jp:00011064,
 author = {MATSUMOTO, Yasuhide and SHIMOTSU, Kyoko and IIJIMA, Mikio and SAHEKI, Takeyori and NAKAGAWA, Shiro},
 issue = {3},
 journal = {鹿児島大学医学雑誌=Medical journal of Kagoshima University},
 month = {2016-10-31},
 note = {Aralar, an isoform of the calcium-binding aspartate-glutamate mitochondrial carrier, is distributed specifically in the brain
and skeletal muscles. The aim of the present study was to investigate behaviors induced by the decreased expression of
aralar in the brain and to assess whether expression of brain tryptophan hydroxylase, a key enzyme in serotonin synthesis,
is correlative with behavioral changes in aralar-deficient mice. In the elevated plus-maze test, heterozygous mice (Aralar^{＋/－})
spent more time in the open arms and showed a significant increase in the number of entries to the open arms compared
to wild-type littermates (Aralar^{＋/＋}). In addition, Aralar^{＋/－} mice spent more time in the light compartment in a light-dark
exploration test compared to Aralar^{＋/＋} mice. Western blot analysis showed a decreased expression of brain tryptophan
hydroxylase in Aralar^{＋/－} mice compared to Aralar^{＋/＋} mice. These results suggested that Aralar^{＋/－} mice exhibit a lower
level of anxiety-like behaviors compared to Aralar^{＋/＋} littermates. This might be correlative with the reduced serotonin
synthesis.},
 pages = {59--65},
 title = {Decreased Level of Anxiety-like Behaviors and Decreased Expression of Brain Tryptophan Hydroxylase in Aralar-deficient Mice : A Preliminary Study},
 volume = {63},
 year = {}
}