{"created":"2023-07-25T08:10:59.377758+00:00","id":11064,"links":{},"metadata":{"_buckets":{"deposit":"7497575c-4224-40f7-a44c-d1a4961ae0f3"},"_deposit":{"created_by":3,"id":"11064","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"11064"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011064","sets":["228:230:5168","57:58:59"]},"author_link":["120256","120253","120264","120263","120265","120255","120252","120266","120254","120262"],"item_7_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Aralar欠損マウスにおける脳内トリプトファン水酸化酵素の発現の減少と不安様行動の減少についての予報"}]},"item_7_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueNumber":"3","bibliographicPageEnd":"65","bibliographicPageStart":"59","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"鹿児島大学医学雑誌=Medical journal of Kagoshima University"}]}]},"item_7_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-01-01"}]},"item_7_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Aralar, an isoform of the calcium-binding aspartate-glutamate mitochondrial carrier, is distributed specifically in the brain\nand skeletal muscles. The aim of the present study was to investigate behaviors induced by the decreased expression of\naralar in the brain and to assess whether expression of brain tryptophan hydroxylase, a key enzyme in serotonin synthesis,\nis correlative with behavioral changes in aralar-deficient mice. In the elevated plus-maze test, heterozygous mice (Aralar^{＋/－})\nspent more time in the open arms and showed a significant increase in the number of entries to the open arms compared\nto wild-type littermates (Aralar^{＋/＋}). In addition, Aralar^{＋/－} mice spent more time in the light compartment in a light-dark\nexploration test compared to Aralar^{＋/＋} mice. Western blot analysis showed a decreased expression of brain tryptophan\nhydroxylase in Aralar^{＋/－} mice compared to Aralar^{＋/＋} mice. These results suggested that Aralar^{＋/－} mice exhibit a lower\nlevel of anxiety-like behaviors compared to Aralar^{＋/＋} littermates. This might be correlative with the reduced serotonin\nsynthesis.","subitem_description_type":"Other"}]},"item_7_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"松元, 泰英"}]},{"nameIdentifiers":[{}],"names":[{"name":"下津, 京子"}]},{"nameIdentifiers":[{}],"names":[{"name":"飯島, 幹雄"}]},{"nameIdentifiers":[{}],"names":[{"name":"佐伯, 武頼"}]},{"nameIdentifiers":[{}],"names":[{"name":"中河, 志朗"}]}]},"item_7_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03685063","subitem_source_identifier_type":"ISSN"}]},"item_7_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00040104","subitem_source_identifier_type":"NCID"}]},"item_7_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_7_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_7_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_7_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MATSUMOTO, Yasuhide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIMOTSU, Kyoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IIJIMA, Mikio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAHEKI, Takeyori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAGAWA, Shiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"AN00040104_v63n3_p59-65.pdf","filesize":[{"value":"235.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00040104_v63n3_p59-65.pdf","url":"https://ir.kagoshima-u.ac.jp/record/11064/files/AN00040104_v63n3_p59-65.pdf"},"version_id":"1b543b7d-b9e5-4b05-b58c-8aea23483040"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"aralar","subitem_subject_scheme":"Other"},{"subitem_subject":"serotonin","subitem_subject_scheme":"Other"},{"subitem_subject":"tryptophan hydroxylase","subitem_subject_scheme":"Other"},{"subitem_subject":"elevated plus-maze test","subitem_subject_scheme":"Other"},{"subitem_subject":"light-dark exploration test","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Decreased Level of Anxiety-like Behaviors and Decreased Expression of Brain Tryptophan Hydroxylase in Aralar-deficient Mice : A Preliminary Study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Decreased Level of Anxiety-like Behaviors and Decreased Expression of Brain Tryptophan Hydroxylase in Aralar-deficient Mice : A Preliminary Study"}]},"item_type_id":"7","owner":"3","path":["59","5168"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-07-03"},"publish_date":"2012-07-03","publish_status":"0","recid":"11064","relation_version_is_last":true,"title":["Decreased Level of Anxiety-like Behaviors and Decreased Expression of Brain Tryptophan Hydroxylase in Aralar-deficient Mice : A Preliminary Study"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-09-01T11:23:12.710478+00:00"}