{"created":"2023-07-25T08:11:01.782202+00:00","id":11111,"links":{},"metadata":{"_buckets":{"deposit":"c8298f42-dad3-4786-bcb5-4bfa283a519c"},"_deposit":{"created_by":29,"id":"11111","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"11111"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011111","sets":["57:80"]},"author_link":["26086"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書　課題番号：21592629　研究代表者：松山孝司 (鹿児島大学大学院医歯学総合研究科准教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"本研究で、感染チタン表面におけるリン酸三カルシウム（β-TCP）パウダーアブレージョン除染効果と処理後の骨形成タンパク（BMP-2）を担持させたポリ乳酸グリコール酸共重合体(PLGA)マイクロカプセルによる細胞親和性を評価した。β-TCPパウダーアブレージョンは、細菌の除去効果を発揮した。BMP-2担持率は、37.5％であった。担持BMP-2は、前駆骨芽細胞様細胞のアルカリフォスファターゼ活性を上昇させた。以上より、β-TCPパウダーアブレージョンによる除染後、担持BMP-2は、チタン表面に骨再生を誘導することが示唆された。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"The purpose of the present study was to evaluate cell biocompatibility and decontamination effect using β-TCP air-abrasion and BMP-2-incorporated PLGA microcapsule. β-TCP air abrasion decontamination led to microscopically visible alterations of the implant surface, however, it seems have a good potential to remove cytotoxic bacterial components from titanium surfaces. BMP-2 encapsulation efficiency from PLGA microcapsules was 37.5%. BMP-2 incorporated PLGA microcapsule elevated alkaline phosphatase activity in preosteoblasts. These results obtained suggest that encapsulated BMP-2 induces bone regeneration on titanium surface after removing cytotoxic bacterial components by β-TCP air-abrasion.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21592629"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松山, 孝司","creatorNameLang":"ja"},{"creatorName":"MATSUYAMA, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26086","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040253900","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2012-05-31"}],"filename":"21592629seika.pdf","filesize":[{"value":"779.5 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"21592629seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/11111/files/21592629seika.pdf"},"version_id":"99be68f8-f719-4947-b6a0-328aff031cc2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"インプラント周囲炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"脱感染処理","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞増殖因子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロカプセル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"骨再生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"2相性作用型再生移植材と細胞移植によるインプラント周囲炎治療法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2相性作用型再生移植材と細胞移植によるインプラント周囲炎治療法の確立","subitem_title_language":"ja"},{"subitem_title":"Establishment of Peri-implantitis treatment using a dual-purpose graft and cell transplantation","subitem_title_language":"en"}]},"item_type_id":"8","owner":"29","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-22"},"publish_date":"2014-12-22","publish_status":"0","recid":"11111","relation_version_is_last":true,"title":["2相性作用型再生移植材と細胞移植によるインプラント周囲炎治療法の確立"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-08-04T07:59:14.281863+00:00"}