{"created":"2023-07-25T08:11:02.229078+00:00","id":11121,"links":{},"metadata":{"_buckets":{"deposit":"e75315a9-ff28-43ea-b1d5-af85f6bf737f"},"_deposit":{"created_by":3,"id":"11121","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"11121"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011121","sets":[]},"author_link":["118072","118074","118073","52729"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effect of the extracts of African plants on ATL cells"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"アフリカ ヤクソウ チュウシュツブツ ノ コウ シュヨウ サイボウ サヨウ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-01"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2010-2011年度科学研究費助成事業(科学研究費補助金(挑戦的萌芽研究))研究成果報告書　課題番号：22659093　研究代表者：栄鶴義人 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_type":"Other"},{"subitem_description":"アフリカの伝統医薬に用いられる薬草抽出物に抗ATL細胞効果を示すものを見出した。この抽出物は、HTLV-1感染細胞には細胞障害性を示したが、健康人由来の末梢リンパ球には細胞障害性を示さずSelective Index(SI)は、>1000倍以上であった。抗ATL細胞活性物質を同定したところ、toosendaninであり、２つの異性体が混在していることが判明した。最終的には、この抽出物で処理したHTLV-1感染リンパ球はアポトーシスを起こした。","subitem_description_type":"Other"},{"subitem_description":"The cytotoxic substance was found in African traditional medicine.\nThis substance is cytotoxic for HTLV-1-infected lymphocyte (ATL cells), but not for normal lymphocytes. The selective index is more than 1000-fold. This substance is toosendanin, consisted of the mixture of two isomers, 12-acetoxyamoorastatin and 29-deacetylsendanin.\nFinally, this substance causes apoptosis of HTLV-1-infected lymphocytes.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"エイズル, ヨシト"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"EIZURU, Yoshito"}]},{"nameIdentifiers":[{}],"names":[{"name":"栄鶴, 義人"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"22659093"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"栄鶴, 義人"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"22659093seika.pdf","filesize":[{"value":"307.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22659093seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/11121/files/22659093seika.pdf"},"version_id":"d9eab3a9-5b10-4107-b0ca-6ed4f55d8b55"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アフリカの伝統医薬","subitem_subject_scheme":"Other"},{"subitem_subject":"抗ATL細胞作用","subitem_subject_scheme":"Other"},{"subitem_subject":"toosendanin","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アフリカ薬草抽出物の抗腫瘍細胞作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アフリカ薬草抽出物の抗腫瘍細胞作用"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-24"},"publish_date":"2014-12-24","publish_status":"0","recid":"11121","relation_version_is_last":true,"title":["アフリカ薬草抽出物の抗腫瘍細胞作用"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:59.380800+00:00"}