@article{oai:ir.kagoshima-u.ac.jp:00011128, author = {Kitano, Motoo and 北野, 元生 and Lehner, Charles E. and Kawashima, Mahito and Taya, Yasushi and Lanphier, Edward H.}, issue = {2}, journal = {南太平洋研究, South Pacific Study}, month = {Mar}, note = {Six mature female sheep were subjected to a series of 0.5, 1, 2 and 4 hour-hyperbaric exposures followed by acute decompressions over a 2.5 year period to simulate recreational and commercial diving. Sheep were euthanized 16 months after the last hyperbaric exposure. Roentgenographic examination of the sheep's long bones revealed dysbaric osteonecrosis (DON) lesions in all the six sheep. Femurs from two of the six sheep with DON were examined for pathological changes. A histopathological evaluation was performed on undecalcified sections of the femurs which showed widespread fatty marrow necrosis of the shafts. Proliferation of granulation tissue, calcification, and ossification were coexistent around the necrotic foci. Endosteal new bone formation also occurred. The significance of fatty marrow necrosis is discussed in comparison with human cases concerning the development and progression of DON.}, pages = {173--182}, title = {Experimentally Induced Dysbaric Osteonecrosis in Sheep : a Histopathological Analysis}, volume = {13}, year = {1993}, yomi = {キタノ, モトオ} }