@article{oai:ir.kagoshima-u.ac.jp:00011321,
 author = {馬嶋, 秀行 and MAJIMA, Hideyuki J.},
 journal = {鹿児島大学歯学部紀要},
 month = {Mar},
 note = {Space environment includes space radiation exposure and microgravity. Space astronauts have been counting over 450 people among over 30 countries. One major concern regarding long-term manned space missions is the effect of accumulative doses of space radiation (daily dose is 0.2 ? 1 mSv). Such missions will inevitably expose astronauts to significant doses, are thought to result in increase of risk, including carcinogenicity, neurotoxicity, and lifespan changes. These effects occur by nuclear and cytosol dysfunction, particular signal transduction or protein synthesis change and mitochondrial damage. In addition, microgravity may affect cellular metabolisms, signal transduction, etc., and might lead into synergistic effects with space radiation, which may result in further increase of risk. To clarify involvement of genome expression by 20 or 30 days exposure of space environment, we will perform soon the space experiment (Neuro Rad) in April, 2010, at International Space Station, launching a human neuroblastoma cell line, SK-N-SH cells, which maintain neuron function. The human space mission and its possible risk are reviewed, and the outline of "Neuro Rad" experiments are introduced.},
 pages = {23--31},
 title = {国際宇宙ステーションにおけるヒト神経細胞宇宙実験「Neuro Rad」 : ヒト長期宇宙滞在　神経細胞に何がおこるか?},
 volume = {30},
 year = {2010}
}