{"created":"2023-07-25T08:03:13.543598+00:00","id":1142,"links":{},"metadata":{"_buckets":{"deposit":"bc12c503-abd4-4d5c-9338-0b1303046afc"},"_deposit":{"created_by":3,"id":"1142","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1142"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00001142","sets":[]},"author_link":["6875","117820","117819"],"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"サルコペニア ニタイスル Akt シグナル オ ヒョウテキ トシタ アタラシイ チリョウホウ ノ カイハツ"},{"subitem_alternative_title":"Novel therapy on sarcopenia by targeting Akt signaling"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-05"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2012-2013年度科学研究費助成事業（研究活動スタート支援）研究成果報告書　課題番号：24890178　研究代表者：赤崎雄一（鹿児島大学・医歯（薬）学総合研究科・助教）","subitem_description_type":"Other"},{"subitem_description":"老化による骨格筋減少症（サルコペニア）に対して、骨格筋特異的にAkt1シグナルを活性化することは、加齢に伴った骨格筋減少症を改善し、内臓脂肪・皮下脂肪を減少させ、脂肪肝を改善した。それにより、糖代謝異常を改善した。以上より、サルコペニアが加齢に伴う代謝異常の重要な因子であり、速筋の量を保持もしくは改善させることは、これらの代謝異常の発症を遅らすための有効な治療法になることが示唆された。","subitem_description_type":"Other"},{"subitem_description":"Akt1-mediated increase in muscle mass led to reductions in fat mass and hepatic steatosis in older animals, and corrected age-associated impairments in glucose metabolism. These results indicate that the loss of lean muscle mass is a  significant contributor to the development of age-related metabolic dysfunction and that interventions that preserve or restore fast/glycolytic muscle may delay the onset of metabolic disease.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"アカサキ, ユウイチ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"AKASAKI, Yuichi"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"24890178"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"赤崎, 雄一"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"24890178_赤崎雄一.pdf","filesize":[{"value":"353.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24890178_赤崎雄一.pdf","url":"https://ir.kagoshima-u.ac.jp/record/1142/files/24890178_赤崎雄一.pdf"},"version_id":"8ea667c4-c8e5-4a46-8144-1c0d82558c6f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨格筋","subitem_subject_scheme":"Other"},{"subitem_subject":"老化","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"脂質","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"サルコペニアに対するAktシグナルを標的とした新しい治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"サルコペニアに対するAktシグナルを標的とした新しい治療法の開発"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-14"},"publish_date":"2015-05-14","publish_status":"0","recid":"1142","relation_version_is_last":true,"title":["サルコペニアに対するAktシグナルを標的とした新しい治療法の開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:45.646036+00:00"}