@article{oai:ir.kagoshima-u.ac.jp:00011434, author = {YAMABE, Hirohiko and KOBASHI, Yoichiro and YUBA, Yoshiaki and HAGA, Hironori and KASHU, Ippei}, issue = {Suppl. 2}, journal = {鹿児島大学医学雑誌=Medical journal of Kagoshima University}, month = {2016-10-31}, note = {A Trial of Application of the Updated Kiel Classification to Extranodal Malignant Lymphomas with Advice of K. Lennert and AC Feller : Proceedings of the Second Seminar on Malignant Lymphoma in Kagoshima, Japan. April 13 - 15, 1994, We report the clinical and pathologic features of a CD56-positive aggressive lymphoma occurring in the skin and subcutaneous tissue of a 44-year-old female. The disease started with skin pigmentation of the left flank, pancytopenia and a high serum LDH level. A skin and subcutaneous biopsy revealed diffuse lymphoblastic-like lymphoma of mainly medium-sized cells with a small area of necrosis. Lymphoma cells showed cytoplasmic azurophilic granules. These cells were positive for CD2, CD56 and HLA-DR but negative for CD3 on flow cytometry, positive for CD2, CD7 and CD56 on frozen sections, and positive for cytoplasmic CD3 and Epstein-Barr virus EBER RNA on paraffin sections. Despite extensive chemotherapy, the patient had a downhill course and died 111 days after admission.}, pages = {167--170}, title = {A Case Report of CD56-Positive Aggressive Lymphoma Involving Skin and Subcutaneous Tissue}, volume = {47}, year = {} }