{"created":"2023-07-25T08:03:14.203931+00:00","id":1152,"links":{},"metadata":{"_buckets":{"deposit":"fe986b61-a98f-45be-bb85-25277de885ea"},"_deposit":{"created_by":18,"id":"1152","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"1152"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00001152","sets":["57:80"]},"author_link":["6905"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-11","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23590280　研究代表者：大塚曜一郎（鹿児島大学・医歯（薬）学総合研究科・客員研究員）","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"本研究の目的は脳内オレキシン神経が、超日リズム形成に関与している可能性を検討することである。野生型マウスで体温、心拍数および行動に同期した一過性の増加がみられ、その間隔は平均90分であり、マウスでもラットと同様な‘超日リズム’が存在することが明らかとなった。遺伝子操作で、オレキシンあるいはオレキシン細胞神経を欠損させる、あるいは光操作でオレキシン神経活動を制御すると超日リズムの変動幅が減弱した。以上の結果は脳内オレキシン神経が超日リズムの発現に重要な役割を果たしていることを示唆する。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"The aim of the present project is to explore brain system that coordinates the ultradian rhythm, focusing orexin, a neuropeptide that is important to promote wakefulness. The project investigated ultradian pattern in genetically-modified mice that have a deficient of orexin or of orexin neurons. In the wild type, body temperature and heat rate increased episodically at every approximately 90  min, confirming the existence of the ultradian rhythm in mice as with rats. In orexin-related transgenic mice, the amplitude of ultradian increase in body temperature and locomotor activity was significantly reduced. The project also employed optogenetically-modified mice in which orexin neuronal activity can be controlled by focal light illumination. Long lasting activation of orexin neurons attenuated the amplitude of the ultradian rhythm. These data suggest that orexin system is important for coordinating ultradian rhythm in body temperature and locomotor activity.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23590280"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大塚, 曜一郎","creatorNameLang":"ja"},{"creatorName":"OOTSUKA, Youichirou","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6905","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000070302403","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"23590280_大塚曜一郎.pdf","filesize":[{"value":"861.4 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23590280_大塚曜一郎.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/1152/files/23590280_大塚曜一郎.pdf"},"version_id":"42a24a8e-6869-4e4f-b94c-fb328ef8941a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"オレキシン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"生体リズム","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子改変マウス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"遺伝子改変マウスを用いた超日生体リズムの脳内発生機構の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"遺伝子改変マウスを用いた超日生体リズムの脳内発生機構の研究","subitem_title_language":"ja"},{"subitem_title":"Role of orexin system in coordinating ultradian rhythm","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-22"},"publish_date":"2015-05-22","publish_status":"0","recid":"1152","relation_version_is_last":true,"title":["遺伝子改変マウスを用いた超日生体リズムの脳内発生機構の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:10.422877+00:00"}