{"created":"2023-07-25T08:03:14.247678+00:00","id":1153,"links":{},"metadata":{"_buckets":{"deposit":"67327613-730e-4a6a-9720-939cd72bcfca"},"_deposit":{"created_by":3,"id":"1153","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1153"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00001153","sets":[]},"author_link":["106316","106317","6629"],"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"シンキ ナノ リュウシ アジュバンド オ リヨウシタ ケンガン ワクチン ノ リンショウ オウヨウ"},{"subitem_alternative_title":"Epidemiological survey for canine tick-borne diseases in Japan"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-04"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23580443　研究代表者：桃井康行（鹿児島大学・獣医学部・教授）","subitem_description_type":"Other"},{"subitem_description":"本研究では、犬の癌ワクチン開発を目標に、腫瘍特異的抗原由来ペプチドを作成し、安全性が高い生体吸収性の新規のナノ粒子アジュバントと共に犬に投与した。その結果、抗体価の上昇がみられた一方で、細胞性免疫の誘導は確認できなかった。担癌動物への投与（1例）では、副作用はみられなかったが、臨床的な効果は確認できなかった。有用な癌ワクチンにするためには改良が必要であるが、癌ワクチン開発について基礎的な情報を得ることができた。また研究の過程で免疫療法の標的となるTRP-2分子の遺伝子単離や多くの腫瘍抗原の発現系の構築に成功した。さらに犬で多発する肥満細胞腫表面でのKIT分子の発現を解析する方法を確立した。","subitem_description_type":"Other"},{"subitem_description":"The aim of this study is to establish new tumor vaccine for canine naturally occurring tumor. We synthesized peptides in reference to epitope of tumor specific antigens. The peptides were conjugated with keyhole limpet hemocyanin and absorbed to the surface of nano-particle (adjuvant). The resultant products successfully induced antibody production against the peptide, however, cellular immunity against the target cells was not detected. Adverse events were not observed in vaccinated dogs but the clinical benefit (objective tumor reduction) was not detected in a dog with lymphoma. We newly reported canine TRP-2 cDNA nucleotide sequence and constructed TRP-2, melan-A,  CD2O-GFP fusion molecule, mammalian expression plasmid. The findings obtained in this study may be helpful to establish canine tumor vaccine.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"モモイ, ヤスユキ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"MOMOI, Yasuyuki"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23580443"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"桃井, 康行"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"23580443_桃井康行.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"23580443_桃井康行.pdf","url":"https://ir.kagoshima-u.ac.jp/record/1153/files/23580443_桃井康行.pdf"},"version_id":"fb072429-9d5e-4144-9259-5f7e30a996a3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"犬","subitem_subject_scheme":"Other"},{"subitem_subject":"癌","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍","subitem_subject_scheme":"Other"},{"subitem_subject":"ワクチン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規ナノ粒子アジュバンドを利用した犬癌ワクチンの臨床応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規ナノ粒子アジュバンドを利用した犬癌ワクチンの臨床応用"}]},"item_type_id":"8","owner":"3","path":["135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-22"},"publish_date":"2015-05-22","publish_status":"0","recid":"1153","relation_version_is_last":true,"title":["新規ナノ粒子アジュバンドを利用した犬癌ワクチンの臨床応用"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-09-01T10:12:50.770113+00:00"}