@article{oai:ir.kagoshima-u.ac.jp:00011539,
 author = {Maeda, Hiroki and 前田, 大輝 and Boldbaatar, Damdinsuren and Kusakisako, Kodai and 草木迫, 浩大 and Galay, Remil Linggatong and Aung, Kyaw Min and Umemiya-Shirafuji, Rika and 白藤（梅宮）, 梨可 and Mochizuki, Masami and 望月, 雅美 and Fujisaki, Kozo and 藤崎, 幸蔵 and Tanaka, Tetsuya and 田仲, 哲也},
 issue = {6},
 journal = {Parasitology research},
 month = {},
 note = {Supplementary Figures, table, figures, Haemaphysalis longicornis is known as one of the most important ticks transmitting Babesia parasites in East Asian countries, including Babesia ovata and Babesia gibsoni, as well as Theileria parasites. H. longicornis is not the natural vector of Babesia bovis and Babesia bigemina. Vector ticks and transmitted parasites are thought to have established unique host–parasite interaction for their survival, meaning that vector ticks may have defensive molecules for the growth control of parasites in their bodies. However, the precise adaptation mechanism of tick-Babesia parasites is still unknown. Recently, cyclophilin A (CyPA) was reported to be important for the development of Babesia parasites in ticks. To reveal a part of their adaptation mechanism, the current study was conducted. An injection of B. bovis-infected RBCs into adult female H. longicornis ticks was found to upregulate the expression profiles of the gene and protein of CyPA in H. longicornis (HlCyPA). In addition, recombinant HlCyPA (rHlCyPA) purified from Escherichia coli exhibited significant inhibitory growth effects on B. bovis and B. bigemina cultivated in vitro, without any hemolytic effect on bovine RBCs at all concentrations used. In conclusion, our results suggest that HlCyPA might play an important role in the growth regulation of Babesia parasites in H. longicornis ticks, during natural acquisition from an infected host. Furthermore, rHlCyPA may be a potential alternative chemotherapeutic agent against babesiosis.},
 pages = {2207--2213},
 title = {Inhibitory effect of cyclophilin A from the hard tick Haemaphysalis longicornis on the growth of Babesia bovis and Babesia bigemina},
 volume = {112},
 year = {2013},
 yomi = {マエダ, ヒロキ and クサキサコ, コウダイ and シラフジ(ウメミヤ), リカ and モチヅキ, マサミ and フジサキ, コウゾウ and タナカ, テツヤ}
}