{"created":"2023-07-25T08:03:14.462744+00:00","id":1158,"links":{},"metadata":{"_buckets":{"deposit":"de7a8cf8-bf86-4be5-9fb0-f24f6cdfa3bb"},"_deposit":{"created_by":18,"id":"1158","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"1158"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00001158","sets":["57:80"]},"author_link":["6920"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-08-18","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23591336　研究代表者：西尾善彦（鹿児島大学・医歯（薬）学総合研究科・教授）","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"ω3PUFAs、なかでもDHAが転写因子Nrf2を活性化することにより、内皮細胞における抗酸化ストレス作用を示すことを示した。さらに、DHAによるNrf2の活性化作用は、DHAのω端の2重結合が参加されて生成される4-hydroxy hexenal (4-HHE) による作用であることが明らかになった。興味深いことに、ω6PUFAsであるアラキドン酸（ARA）より同様の機序で生成される4-hydroxy nonenal (4-HNE) にも同様の作用が認められ4-HHEや4-HNEは培養内細胞を酸化ストレスから保護する作用が認められた。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"We tested whether n-3 PUFAs showed antioxidant activity through the activation of Nrf2, a master transcriptional factor for antioxidant genes. C57BL/6 or Nrf2-/- mice were fed a fish-oil diet. Fish-oil diet significantly increased the expression of heme  oxygenase-1  (H0-1), and endothelium-dependent vasodilation in the aorta of C57BL/6 mice, but not in Nrf2-/- mice. Furthermore, we observed that 4-hydroxy hexenal (4-HHE), an end-product of n-3 PUFA peroxidation, was significantly increased in the aorta of C57BL/6 mice, accompanied by intra-aortic predominant increase in DHA rather than that in EPA. Human umbilical vein endothelial cells were incubated with DHA or EPA. We found that DHA, but not EPA, markedly increased intracellular 4-HHE, and nuclear expression and DNA binding of Nrf2. Both DHA and 4-HHE also  increared the expressions of Nrf2 target genes including  HO-1. Furthermore, DHA prevented oxidant-induced cellular damage and this effect was disappeared by the siRNA of Nrf2.is mechanism in our study. Exercise improved neurobehavioral functions, indicating that the reduced deficits are related with the exercise-mediated decreased neuronal apoptotic cell death. Early motor exercise aid functional recovery by stimulating neurorepair mechanisms after stroke.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23591336"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西尾, 善彦","creatorNameLang":"ja"},{"creatorName":"NISHIO, Yoshohiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6920","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040281084","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"23591336_西尾善彦（修正完了版）.pdf","filesize":[{"value":"338.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23591336_西尾善彦（修正完了版）.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/1158/files/23591336_西尾善彦（修正完了版）.pdf"},"version_id":"dd37f710-75db-4ddc-9b88-0722ea073ebb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"酸化ストレス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"血管内皮","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"多価不飽和脂肪酸を用いた血管内皮抗酸化システムの活性化戦略の意義を明らかにする。","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"多価不飽和脂肪酸を用いた血管内皮抗酸化システムの活性化戦略の意義を明らかにする。","subitem_title_language":"ja"},{"subitem_title":"The effects of omega-3 PUTA on vascular function","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-26"},"publish_date":"2015-05-26","publish_status":"0","recid":"1158","relation_version_is_last":true,"title":["多価不飽和脂肪酸を用いた血管内皮抗酸化システムの活性化戦略の意義を明らかにする。"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:10.216113+00:00"}