{"created":"2023-07-25T08:11:24.138772+00:00","id":11587,"links":{},"metadata":{"_buckets":{"deposit":"b869e0a7-cf1b-472d-9666-4bd9cf65d7d9"},"_deposit":{"created_by":3,"id":"11587","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"11587"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011587","sets":[]},"author_link":["118076","55417","118077","24996","118075","118078"],"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"TCR-Vβ キョウイテキ ヒトコウタイ オ モチイタ Tサイボウセイ リンパシュ チリョウヤク ノ カイハツ"},{"subitem_alternative_title":"A study of TCR-Vβ targeted antibody therapy against human T cell lymphoma"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-16"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2012年度科学研究費助成事業(科学研究費補助金(挑戦的萌芽研究)研究成果報告書　課題番号：23659286　研究代表者：有馬直道(鹿児島大学・大学院医歯学総合研究科・教授)","subitem_description_type":"Other"},{"subitem_description":"施設内研究倫理委員会承認下に、同意を得られたATL患者末梢血白血病細胞のTCRVβのレパトアがVβ2であることを確認。抽出RNAより5’RACE法を用い、TCRのαとβの全長をクローニングし単離した。TCRβの発現ベクターをレンチウイルスベクター系により樹立し、Jurkat細胞株に感染し、TCRβ2の発現系を確立した。同時にヒト抗体重鎖・軽鎖発現ファージライブラリーの構築を、正常ヒトリンパ球RNAをもとに構築した。","subitem_description_type":"Other"},{"subitem_description":"Under admission of IRB, repertoire of TCRVb of leukemic cells derived from an ATL patient was demonstrated Vb2. Full length of TCR α and β were separated from extracted RNA by 5’RACE method. TCRb expressing vector was established using lenti-virus bector system, and infected into Jurkat cells which expresses successfully trnsfected TCR2 protein. On the other hands, human anbibody heavy and light chain expressing phage library was constructed using normal health lymphocyte RNA. Using these two materials, we further study establishment of malignant T cell targeted antibody therapy.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"アリマ, ナオミチ"}]},{"nameIdentifiers":[{}],"names":[{"name":"イトウ, ユウジ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ARIMA, Naomichi"}]},{"nameIdentifiers":[{}],"names":[{"name":"ITO, Yuji"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491.5","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23659286"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"有馬, 直道"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"伊東, 祐二"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"23659286.pdf","filesize":[{"value":"214.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"23659286.pdf","url":"https://ir.kagoshima-u.ac.jp/record/11587/files/23659286.pdf"},"version_id":"d7f85a90-3a86-4649-b75b-90a1fc294170"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"抗体療法","subitem_subject_scheme":"Other"},{"subitem_subject":"TCR-Vβ","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞性リンパ腫","subitem_subject_scheme":"Other"},{"subitem_subject":"治療薬","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"TCR-Vβ特異的ヒト抗体を用いたT細胞性リンパ腫治療薬の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"TCR-Vβ特異的ヒト抗体を用いたT細胞性リンパ腫治療薬の開発"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-01"},"publish_date":"2013-10-01","publish_status":"0","recid":"11587","relation_version_is_last":true,"title":["TCR-Vβ特異的ヒト抗体を用いたT細胞性リンパ腫治療薬の開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:19:05.268647+00:00"}