{"created":"2023-07-25T08:11:24.184627+00:00","id":11588,"links":{},"metadata":{"_buckets":{"deposit":"9d7bde7a-212a-4296-bcd6-5d14d55abc65"},"_deposit":{"created_by":18,"id":"11588","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"11588"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011588","sets":["57:80"]},"author_link":["55422","55423"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2012年度科学研究費助成事業(科学研究費補助金(挑戦的萌芽研究)研究成果報告書　課題番号：23659435　研究代表者：井上博雅(鹿児島大学・大学院医歯学総合研究科・教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"重症難治性喘息や肺線維症などの難治性呼吸器疾患の治療法は確立しておらず、その病態解析から新規治療法の確立が必要である。本研究は、難治性呼吸器疾患の新たな治療標的の探索および新規抗体療法の開発を目的とした。アレルギー性喘息や肺線維症のマウスモデルを用いて、これまで呼吸器における役割が不明であった分泌性ホスホリパーゼA2やアンジオポエチン様蛋白、さらに血管内皮細胞増殖因子が、喘息や肺線維症の病態形成において重要な役割を担っていることを確認した。これらのメディエーターの作用を制御する抗体の開発は、難治性呼吸器疾患に対する画期的な治療法として期待できる。特に、抗血管内皮細胞増殖因子抗体を肺局所で長期間産生するベクターは、肺線維症に対する新しい治療法として有用であると考えられた。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Severe asthma and idiopathic pulmonary fibrosis are chronic lung diseases of notable unmet medical need. Focusing on secretory phospholipase A2 and angiopoietin-like proteins, we studied here the mechanisms underlying allergic asthma and lung fibrosis to find new therapeutic targets with novel antibody therapy. Deficiency of a group of secretory phospholipase A2 augmented asthma phenotypes in a mouse model. Expression of a member of angiopoietin-like proteins was increased in the lung tissues from a mouse model of lung fibrosis and from the patients with pulmonary fibrosis. We also found that vascular endothelial growth factor (VEGF) plays an important role in pathogenesis of lung fibrosis in mice, and our findings suggest that the genetic delivery of monoclonal anti-VEGF antibody is a novel alternative to conventional monoclonal antibody therapy.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493.36","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23659435"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井上, 博雅","creatorNameLang":"ja"},{"creatorName":"INOUE, Hiromasa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"55422","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000030264039","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"渡辺, 正樹","creatorNameLang":"ja"},{"creatorName":"WATANABE, Masaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"55423","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090398298","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"23659435.pdf","filesize":[{"value":"214.1 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23659435.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/11588/files/23659435.pdf"},"version_id":"f9b8b484-e780-4072-83e5-529a86385277"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"難治性呼吸器疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"気管支喘息","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"肺線維症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"抗体療法","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"難治性喘息に対する新規抗体療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"難治性喘息に対する新規抗体療法の開発","subitem_title_language":"ja"},{"subitem_title":"Development of novel antibody therapy for refractory asthma","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-10-01"},"publish_date":"2013-10-01","publish_status":"0","recid":"11588","relation_version_is_last":true,"title":["難治性喘息に対する新規抗体療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:52.356833+00:00"}