{"created":"2023-07-25T08:11:24.231285+00:00","id":11589,"links":{},"metadata":{"_buckets":{"deposit":"7a0dadcd-c133-4be3-96af-a0e4e2077748"},"_deposit":{"created_by":3,"id":"11589","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"11589"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011589","sets":[]},"author_link":["118083","13246","118086","118084","118085","13155"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Development of the dental implant with a periodontal tissue using stem cells"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"iPS サイボウ オ モチイタ シシュウ ソシキ サイセイガタ インプラント ノ カイハツ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-30"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2012年度科学研究費助成事業(科学研究費補助金(挑戦的萌芽研究)研究成果報告書　課題番号：23659922　研究代表者：野口和行(鹿児島大学・大学院医歯学総合研究科・教授)","subitem_description_type":"Other"},{"subitem_description":"本研究は、エナメルマトリックス蛋白を表面固定したチタン（Ti EMD）上での幹細胞の動態を調べることを目的とした。本研究ではiPS細胞の間葉系幹細胞への分化がうまくいかなかったため、ヒト間葉系幹細胞（hMSC）とヒト歯根膜細胞（hPDL）を用いた。Ti EMD上で培養することで、hMSCとhPDLいずれもVEGFの産生が亢進した。歯根膜細胞のマーカーであるPeriostinとPLAP-1のmRNA発現解析では、hMSCとhPDLともにTi EMD上で培養することでPeriostinとPLAP-1の発現が亢進した。","subitem_description_type":"Other"},{"subitem_description":"Enamel matrix derivative (EMD) plays an important role in periodontal tissue regeneration by inducing angiogenesis. The present study was aimed to evaluate the kinetics of human mesenchymal stem cells (hMSC) or human periodontal ligament fibroblasts (hPDLs) on the titanium surface with biochemical treatment, namely, with or without EMD immobilization. EMD could be easily immobilized by tresyl chloride-activation technique. In the both hMSCs and hPDLs, the production of VEGF was significantly increased on titanium surface with EMD immobilization than other control groups. Furthermore, the mRNA levels of Periostin and PLAL-1, which were the markers of a periodontal ligament, were up-regulated in both hMSCs and hPDLs on titanium surface with EMD immobilization than other control groups. Further refinement of this approach will facilitate the development of clinically relevant methods for PDL regeneration on titanium implants in humans.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ノグチ, カズユキ"}]},{"nameIdentifiers":[{}],"names":[{"name":"サコダ, ケンジ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"NOGUCHI, Kazuyuki"}]},{"nameIdentifiers":[{}],"names":[{"name":"SAKODA, Kenji"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23659922"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野口, 和行"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"迫田, 賢二"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"23659922.pdf","filesize":[{"value":"597.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"23659922.pdf","url":"https://ir.kagoshima-u.ac.jp/record/11589/files/23659922.pdf"},"version_id":"f87a26b1-08ca-4113-9fc8-8717a92d27d0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"歯周組織","subitem_subject_scheme":"Other"},{"subitem_subject":"エナメルマトリックスタンパク","subitem_subject_scheme":"Other"},{"subitem_subject":"幹細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"インプラント","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"iPS細胞を用いた歯周組織再生型インプラントの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"iPS細胞を用いた歯周組織再生型インプラントの開発"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-01"},"publish_date":"2013-10-01","publish_status":"0","recid":"11589","relation_version_is_last":true,"title":["iPS細胞を用いた歯周組織再生型インプラントの開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:45.171412+00:00"}