{"created":"2023-07-25T08:11:24.458645+00:00","id":11594,"links":{},"metadata":{"_buckets":{"deposit":"2193ca3d-48ad-466f-890e-277adcd6ca6a"},"_deposit":{"created_by":18,"id":"11594","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"11594"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011594","sets":["82:83"]},"author_link":["55442"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-05-20","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2012年度科学研究費助成事業(科学研究費補助金(若手研究(B))研究成果報告書　課題番号：23791553　研究代表者：喜多芳昭(鹿児島大学・医学部・歯学部附属病院・特任教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"microarrayを用いて幹細胞ニッチに関わる遺伝子群を同定した． （1）細胞周期に関係する1遺伝子に対し，発現・機能解析を行い，腫瘍深達度，リンパ管侵襲，病期，遠隔転移，予後と相関することを見出した．（2）糖代謝に関連する遺伝子Glut-1が含まれており，免疫染色で発現を確認，糖代謝を利用したPET検査の結果を用いFDG集積と相関することを見出した．以上，食道表在癌におけるPET検査の意義として論文発表を行った．","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"We found some genes regarding as niche of cancer stem cell by using oligomicroarray with laser micro dissection method. (1) One of above genes, which concerns cell cycle, was evaluated the expression and function and associated with invasion of tumor, lymphatic invasion, clinical stage, distant metastasis, and prognosis. (2) We extract Glut-1 which is regarding glucose metabolism, and evaluated the expression of the cell membrane of tumor cell. After we consider the result of PET-CT which is the diagnostic modality using glucose uptake into the tumor cell, we investigated that Glut-1 expression has correlate with FDG accumulation. Finally, we submitted this result to Annals of Surgical Oncology and they accepted as follows.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494.644","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23791553"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"喜多, 芳昭","creatorNameLang":"ja"},{"creatorName":"KITA, Yoshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"55442","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000030570692","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"23791553.pdf","filesize":[{"value":"299.0 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23791553.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/11594/files/23791553.pdf"},"version_id":"2555e2f8-6d17-42d8-8dbe-0e03f6df6c9d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"微小環境","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"癌幹細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロアレイ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞実験","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"幹細胞ニッチからの食道扁平上皮癌リンパ節転移機構の解明と治療","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"幹細胞ニッチからの食道扁平上皮癌リンパ節転移機構の解明と治療","subitem_title_language":"ja"},{"subitem_title":"Investigation of the lymph node metastasis mechanism throughout niche around cancer stem cell in esophageal squamous cell carcinoma","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["83"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-10-01"},"publish_date":"2013-10-01","publish_status":"0","recid":"11594","relation_version_is_last":true,"title":["幹細胞ニッチからの食道扁平上皮癌リンパ節転移機構の解明と治療"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-10T05:23:20.187667+00:00"}