{"created":"2023-07-25T08:11:24.591950+00:00","id":11597,"links":{},"metadata":{"_buckets":{"deposit":"ada88b42-123c-41c8-85af-a9a75db1415e"},"_deposit":{"created_by":18,"id":"11597","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"11597"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011597","sets":["57:78"]},"author_link":["117524","117525","117526","117527","117528","117529","117530","117531","117532","117533","117534"],"item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"PLoS ONE","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-07-09","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"The Notch pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal development. In addition, the Notch pathway plays an important role in controlling tumorigenesis. However, the role of RBPJ, a transcription factor in the Notch pathway, in the development of tumors is largely unknown. In this study, we focused on the role of RBPJ in the pathogenesis of rhabdomyosarcoma (RMS). Our data showed that Notch pathway genes were upregulated and activated in human RMS cell lines and patient samples. Inhibition of the Notch pathway by a csecretase inhibitor (GSI) decreased the in vitro proliferation of RMS cells. Knockdown of RBPJ expression by RNAi inhibited the anchorage-independent growth of RMS cells and the growth of xenografts in vivo. Additionally, overexpression of RBPJ promoted the anchorage-independent growth of RMS cells. Further, we revealed that RBPJ regulated the cell cycle in RMS xenograft tumors and decreased proliferation. Our findings suggest that RBPJ regulates the RMS growth, and that the inhibition of RBPJ may be an effective therapeutic approach for patients with RMS.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science","subitem_publisher_language":"en"}]},"item_6_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0039268","subitem_relation_type_select":"DOI"}}]},"item_6_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 Nagao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_6_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"19326203","subitem_source_identifier_type":"EISSN"}]},"item_6_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494.5","subitem_subject_scheme":"NDC"}]},"item_6_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nagao, Hiroko","creatorNameLang":"en"},{"creatorName":"ナガオ, ヒロコ","creatorNameLang":"ja-Kana"},{"creatorName":"永尾, 宗子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117524","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Setoguchi, Takao","creatorNameLang":"en"},{"creatorName":"セトグチ, タカオ","creatorNameLang":"ja-Kana"},{"creatorName":"瀬戸口, 啓夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117525","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamoto, Sho","creatorNameLang":"en"},{"creatorName":"キタモト, ショウ","creatorNameLang":"ja-Kana"},{"creatorName":"北本, 祥","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117526","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishidou, Yasuhiro","creatorNameLang":"en"},{"creatorName":"イシドウ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"石堂, 康弘","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117527","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagano, Satoshi","creatorNameLang":"en"},{"creatorName":"ナガノ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"永野, 聡","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117528","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokouchi, Masahiro","creatorNameLang":"en"},{"creatorName":"ヨコウチ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"横内, 雅博","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117529","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abematsu, Masahiko","creatorNameLang":"en"},{"creatorName":"アベマツ, マサヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"棈松, 昌彦","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117530","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawabata, Naoya","creatorNameLang":"en"},{"creatorName":"カワバタ, ナオヤ","creatorNameLang":"ja-Kana"},{"creatorName":"川畑, 直也","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117531","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Shingo","creatorNameLang":"en"},{"creatorName":"マエダ, シンゴ","creatorNameLang":"ja-Kana"},{"creatorName":"前田, 真吾","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117532","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yonezawa, Suguru","creatorNameLang":"en"},{"creatorName":"ヨネザワ, スグル","creatorNameLang":"ja-Kana"},{"creatorName":"米澤, 傑","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117533","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komiya, Setsuro","creatorNameLang":"en"},{"creatorName":"コミヤ, セツロウ","creatorNameLang":"ja-Kana"},{"creatorName":"小宮, 節郎","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"117534","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"RBPJ Is a Novel Target for Rhabdomyosarcoma 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