@article{oai:ir.kagoshima-u.ac.jp:00011608,
 author = {Sasaki, Ken and 佐々木, 健 and Natsugoe, Shoji and 夏越, 祥次 and Ishigami, Sumiya and 石神, 純也 and Matsumoto, Masataka and 松本, 正隆 and Okumura, Hiroshi and 奥村, 浩 and Setoyama, Tetsuro and 瀬戸山, 徹郎 and Uchikado, Yasuto and 内門, 泰斗 and Kita, Yoshiaki and 喜多, 芳昭 and Tamotsu, Kiyokazu and 保, 清和 and Sakamoto, Akihiko and サカモト, アキヒコ and Owaki, Tetsuhiro and 大脇, 哲洋 and Aikou, Takashi and 愛甲, 孝},
 issue = {158},
 journal = {Journal of Experimental and Clinical Cancer Research},
 month = {},
 note = {Background: Twist is a basic helix-loop-helix (bHLH) transcriptional factor that has been identified to play an important role in epithelial-mesenchymal transition (EMT)-mediated metastasis through the regulation of E-cadherin expression. However, few authors have examined the expression of Twist and E-cadherin and their prognostic value in patients with esophageal squamous cell carcinoma (ESCC). The purpose of this study is to evaluate the clinical significance of Twist and E-cadherin expression in ESCC.
Methods: We immunohistochemically investigated the relationship between their expression and clinicopathological factors including prognosis in surgical specimens of primary tumors in 166 patients with ESCC.
Results: The expression rate of high Twist was 42.0% and that of preserved E-cadherin was 40.4%. The expression of high Twist and reduced E-cadherin was significantly associated with depth of tumor invasion, lymph node metastasis, distant nodal metastasis, stage and lymphatic invasion, and poor prognosis. High Twist expression significantly correlated with reduced E-cadherin expression. In the preserved E-cadherin group, the 5-year survival rate was better for patients who were low for Twist expression than for those who were high for Twist expression. Multivariate analysis indicated that the combination of low Twist and preserved E-cadherin expression was an independent prognostic factor along with tumor depth, distant nodal metastasis and E-cadherin expression.
Conclusions: Evaluation of Twist and E-cadherin expressions should be useful for determining tumor properties, including prognosis, in patients with ESCC.},
 title = {Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma},
 volume = {28},
 year = {2009},
 yomi = {ササキ, ケン and ナツゴエ, ショウジ and イシガミ, スミヤ and マツモト, マサタカ and オクムラ, ヒロシ and セトヤマ, テツロウ and ウチカド, ヤスト and キタ, ヨシアキ and タモツ, キヨカズ and オオワキ, テツヒロ and アイコウ, タカシ}
}