@article{oai:ir.kagoshima-u.ac.jp:00011670,
 author = {小川, 信 and 出先, 亮介 and 金子, 公一 and 保, 清和 and 小代, 正隆 and 夏越, 祥次},
 issue = {1},
 journal = {鹿児島大学医学雑誌, Medical journal of Kagoshima University},
 month = {},
 note = {We experienced two cases of panperitonitis due to colon cancer for which a therapy both with human soluble thrombomodulin (rTM) and Polymyxin B-immobilized fiber column-direct hemoperfusion(PMX-DHP) was effective. An
80-year-old woman was referred to our hospital by ileus. Stoma at the transverse colon was made for obstruction of colon
by rectal cancer. Intensive care was done for postoperative pre-DIC and ARDS. Sequential Organ Failure Assesment Score
(SOFA score) improved from eight to two owing to effect of the combination therapy. Another 82-year-old woman was referred to our hospital as lower intestinal perforation was suspected. Abdominal CT examination revealed sigmoid colon perforation due to rectal cancer. We performed urgently recto-sigmoidectomy and stoma formation of sigmoid colon. Although she suffered from DIC after surgery, SOFA score improved from 11 to 7 by the combination therapy. It was thought that the combination therapy was effective for inflammatory DIC caused by acute panperitonitis by colon cancer.},
 pages = {19--24},
 title = {遺伝子組換え型ヒトトロンボモジュリン製剤とPMX-DHPの併用療法が有効であった大腸癌急性汎発性腹膜炎の２例},
 volume = {65},
 year = {2013}
}