{"created":"2023-07-25T08:11:43.612477+00:00","id":11965,"links":{},"metadata":{"_buckets":{"deposit":"dfa42e19-56b2-4245-91c2-ca585fd91e51"},"_deposit":{"created_by":3,"id":"11965","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"11965"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011965","sets":["31:172:206"]},"author_link":["36768","112122","112121"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Intestinal Transportation in CLAWN Miniature Swine: Establishment of Orthotopic Model and Roles of Chimerisms. HVG and GVH Responses"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"GvHR ニヨル ドナー キメラ ゾウキョウ サヨウ ニ モトズク ダイドウブツ ショウチョウ イショク デノ カクシンテキ メンエキ カンヨウ ユウドウホウ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-04"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（B））研究成果報告書　課題番号：23390314　研究代表者：山田和彦（鹿児島大学・医用ミニブタ・先端医療開発研究センター・教授）","subitem_description_type":"Other"},{"subitem_description":"鹿児島大学で開発された国内唯一の組織適合性抗原が確立したクラウンミニブタを用い、同所性小腸移植慢性実験モデルの開発に国内で初めて成功し、小腸移植において、持ち込みリンパ球による非常に強い移植直後のサイトカインシンドロームによる炎症性サイトカインの放出とその対処戦略、さらに確立した同所性小腸移植において、短期免疫抑制療法のみで3か月を超える移植小腸機能によるレシピエントの生存を確認した。これらの成果は論文投稿の段階に至っている。","subitem_description_type":"Other"},{"subitem_description":"With this grant support, we have successfully established a survival orthotopic intestinal transplantation procedure in MHC-inbred CLAWN miniature swine. To our knowledge, this is the first successful long term, life supporting preclinical intestinal transplantation model in Japan. Our results demonstrated (1) compartment syndrome following heterotopic intestine transplantation in CLAWN miniature swine, (2) greater than 3 months acceptance of a life-supporting intestinal grafts, and (3) severe and a cute inflammatory cytokine storm in the induction period as well as a strategy to inhibit the cytokine storm (manuscript in preparation).","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ヤマダ, カズヒコ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"YAMADA, Kazuhiko"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23390314"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 和彦"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"23390314_山田和彦.pdf","filesize":[{"value":"90.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"23390314_山田和彦.pdf","url":"https://ir.kagoshima-u.ac.jp/record/11965/files/23390314_山田和彦.pdf"},"version_id":"6e2d5674-1af1-4554-98dc-c594b9b683df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"小腸移植","subitem_subject_scheme":"Other"},{"subitem_subject":"ミニブタ","subitem_subject_scheme":"Other"},{"subitem_subject":"組織適合性抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"GvH","subitem_subject_scheme":"Other"},{"subitem_subject":"キメラ","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"GvHRによるドナーキメラ増強作用に基づく大動物小腸移植での革新的免疫寛容誘導法","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GvHRによるドナーキメラ増強作用に基づく大動物小腸移植での革新的免疫寛容誘導法"}]},"item_type_id":"8","owner":"3","path":["206"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-19"},"publish_date":"2015-05-19","publish_status":"0","recid":"11965","relation_version_is_last":true,"title":["GvHRによるドナーキメラ増強作用に基づく大動物小腸移植での革新的免疫寛容誘導法"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-09-01T10:19:01.019536+00:00"}