{"created":"2023-07-25T08:11:43.749949+00:00","id":11968,"links":{},"metadata":{"_buckets":{"deposit":"0c88fc97-aea8-4f4c-9175-12c4c0efb140"},"_deposit":{"created_by":3,"id":"11968","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"11968"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011968","sets":[]},"author_link":["118092","118091","27954"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The study of periodontal regeneration by using de-differentiated fat cells"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"ヒト セイジュク シボウ サイボウ ユライ ダツブンカ シボウ サイボウ （DFAT） オ モチイタ シシュウ ソシキ サイセイ ニカンスル ケンキュウ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-06"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2012-2013年度科学研究費助成事業（若手研究（B））研究成果報告書　課題番号：24792147　研究代表者：吉元剛彦（鹿児島大学・医歯（薬）学総合研究科・客員研究員）","subitem_description_type":"Other"},{"subitem_description":"脱分化脂肪細胞（DFAT）は成熟脂肪細胞から生じる多分化能を有する細胞群である。本研究の目的は歯周組織欠損の特に骨再生に対する応用に向けた基礎的研究として、ラットより分離・培養したrat DFAT（rDFAT）を用い、その骨形成能について評価することであった。まず、rDFATの脂肪滴・石灰化物形成を確認後、ラット頭蓋骨欠損モデルにおいてrDFATの骨形成能を評価したところコントロールおよび担体のみの群では骨のブリッジングを認めなかった。一方、rDFAT＋担体群では新生骨によるブリッジング1個体にのみが認められ、骨分化刺激rDFAT＋担体群では4個体において新生骨のブリッジングが認められた。","subitem_description_type":"Other"},{"subitem_description":"Dedifferentiated fat (DFAT) cells, which are isolated from mature adipocytes using the ceiling culture method, exhibit similar characteristics to mesenchymal stem cells. The aim of the present study was to evaluate the ability of bone regeneration by using rat DFAT (rDFAT) cells for the basic research of periodontal regenerative therapy. First, mineralization and lipid formation were observed in rDFATs cultured in the each differentiation medium. Next, the bone forming ability of rDFAT was evaluated by using rat calvarial critical size defect model. The defects were treated by one of the following procedures: scaffold+osteo-differentiated rDFATs (1); scaffold+rDFATs (2); scaffold  (3); no implantation  (4). The animals were euthanized at 6 weeks after the surgery for histological evaluation. Complete closure of bone defect was not observed in the experimental groups of (3) and (4), but observed in the 1 specimen of group (2) and 4 specimens of group  (4).","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ヨシモト, タケヒコ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"YOSHIMOTO, Takehiko"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"24792147"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉元, 剛彦"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"24792147_吉元剛彦.pdf","filesize":[{"value":"480.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24792147_吉元剛彦.pdf","url":"https://ir.kagoshima-u.ac.jp/record/11968/files/24792147_吉元剛彦.pdf"},"version_id":"c6d6c718-e81e-4eac-9b4c-6fe8fd3a142e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DFAT","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト成熟脂肪細胞由来脱分化脂肪細胞（DFAT）を用いた歯周組織再生に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト成熟脂肪細胞由来脱分化脂肪細胞（DFAT）を用いた歯周組織再生に関する研究"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-19"},"publish_date":"2015-05-19","publish_status":"0","recid":"11968","relation_version_is_last":true,"title":["ヒト成熟脂肪細胞由来脱分化脂肪細胞（DFAT）を用いた歯周組織再生に関する研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:48.413331+00:00"}