{"created":"2023-07-25T08:11:44.507467+00:00","id":11985,"links":{},"metadata":{"_buckets":{"deposit":"b4217595-affc-4f36-b729-3a6249b7b9cb"},"_deposit":{"created_by":18,"id":"11985","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"11985"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011985","sets":["57:80"]},"author_link":["14879"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-10","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業(基盤研究(C))研究成果報告書 課題番号:23593037 研究代表者:前田綾(鹿児島大学・医歯(薬)学総合研究科・助教)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"骨芽細胞の機械的刺激によるケモカインMIP-2とMCP-1の発現誘導には構成的なIL-1βを必要とすること、また、それがIL-1レセプターおよびTLRのアダプタータンパクであるMyD88を介することが明らかとなった。よって、MyD88を介したシグナル伝達系が、矯正治療における骨改造の初期反応に関与することが示唆された。また、IL-1βのタンパク濃度が高い状況下では、これらの反応を促進させる可能性が示唆された。臨床研究では、歯根長は咬合接触と関連し、不良な骨架橋は、早期に矯正治療を開始した場合に良好な骨架橋になる可能性が認められ、機械的刺激が歯根形成や移植骨の骨改造に関連することが示唆された。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"We found that the constitutive expression of IL-lbeta is essential for the induced expression for MIP-2 and MCP-1 in osteoblasts by mechanical stresses in a manner dependent on MyD88, an adaptor molecule for IL-1 receptor and TLRs. Thus, it is suggested that MyD88 signaling pathway is involved in bone remodeling in the early phase of orthodontic treatment. Our findings also indicated that high level concentrations of IL-lbeta may promote inflammatory responses of osteoblasts induced by mechanical stress. In the clinical research, it was found that the dental root length was related to the loss of occlusal contact. Additionally, some of the poor bone bridges were improved by orthodontic tooth movement in the early phase after bone graft. These results suggested that the functional stress by occlusal force and mechanical stress may promote root-length formation and bone remodeling.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23593037"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"前田, 綾","creatorNameLang":"ja"},{"creatorName":"MAEDA, Aya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"14879","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000010457666","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"23593037_前田綾.pdf","filesize":[{"value":"164.2 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23593037_前田綾.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/11985/files/23593037_前田綾.pdf"},"version_id":"005b56ef-5622-4136-81f1-765e5821773c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"機械的刺激","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"矯正治療","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"骨改造","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症性反応","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ケモカイン ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトカイン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"TLR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞内シグナル伝達","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"歯周病原因子と過大な機械的刺激が歯の移動の細胞シグナリング機構に及ぼす影響の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"歯周病原因子と過大な機械的刺激が歯の移動の細胞シグナリング機構に及ぼす影響の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of the effects of periodontal pathogenic factor and excessive mechanical stress on signaling pathway of orthodontic tooth movement","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-22"},"publish_date":"2015-05-22","publish_status":"0","recid":"11985","relation_version_is_last":true,"title":["歯周病原因子と過大な機械的刺激が歯の移動の細胞シグナリング機構に及ぼす影響の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:24:49.375344+00:00"}