{"created":"2023-07-25T08:11:44.858813+00:00","id":11993,"links":{},"metadata":{"_buckets":{"deposit":"1afd4c4e-f0d6-4d00-b19d-60aa5965c6d4"},"_deposit":{"created_by":18,"id":"11993","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"11993"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011993","sets":["131:135"]},"author_link":["29942"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-05-29","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23590547　研究代表者：小原恭子（鹿児島大学・獣医学部・教授）","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"C型肝炎ウイルス（HCV）によるBリンパ腫発症機序を解明するため、B細胞でHCV全長を発現するトランスジェニック（Tg）マウスを用いて解析した。本マウスの約25％でBリンパ腫が発症する。マイクロアレイを用いた網羅的な解析を行った結果、Bリンパ腫発症群では、Fos, C3, Lymphotoxin βR, A20, NF-κBの発現が強く修飾されていた。Bリンパ腫組織ではNF-κBが核に移行して活性化されていることが明らかとなった。さらに、肝がんや肺がんなどでの発現低下も報告され、腫瘍抑制効果があるとされるmiR-26bの発現がBリンパ腫組織では低下している事が明らかとなった。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Hepatitis C virus (HCV) infection leads to the  development of hepatic diseases, as well as extra hepatic disorders such as B-cell  non-Hodikin's lymphoma  (B-NHL). To reveal the molecular signaling pathways responsible for HCV-associated B-NHL development, we utilized transgenic (Tg) mice that express the full-length HCV genome specifically in B cells and develop non-Hodgkin type B-cell lymphomas (BCLs). The gene expression profiles in B cells from BCL-developing HCV-Tg mice, from BCL-non-deceloping HCV-Tg mice, and from BCL-non-developing HCV-negative mice were analyzed by genome-wide microarray. Markedly modified genes such as Fos, C3, LTbR, A20, NF-kB and miR-26b in BCLs were further characterized using specific assays. We propose that activation of both canonical and alternative NF-kB signaling pathways and down-regulation of miR-26b contribute to the development of HCV-associated B-NHL.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23590547"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小原, 恭子","creatorNameLang":"ja"},{"creatorName":"KOHARA, Kyoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"29942","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000020225478","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"23590547_小原恭子.pdf","filesize":[{"value":"471.3 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23590547_小原恭子.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/11993/files/23590547_小原恭子.pdf"},"version_id":"cd3ee869-ccdf-4f79-8327-cc4d29de5269"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"C型肝炎ウイルス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Bリンパ腫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"microarray","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"A20","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NF-kB","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"miR-26b","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"C型肝炎細胞がB細胞を介して発揮する病原性のインパクト","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"C型肝炎細胞がB細胞を介して発揮する病原性のインパクト","subitem_title_language":"ja"},{"subitem_title":"Impact of hepatitis C virus infection in B cells pathogenesis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["135"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-22"},"publish_date":"2015-05-22","publish_status":"0","recid":"11993","relation_version_is_last":true,"title":["C型肝炎細胞がB細胞を介して発揮する病原性のインパクト"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-08T08:50:29.855930+00:00"}