{"created":"2023-07-25T08:11:44.902335+00:00","id":11994,"links":{},"metadata":{"_buckets":{"deposit":"5b6c671b-c899-482a-a09f-336d649e5448"},"_deposit":{"created_by":18,"id":"11994","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"11994"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00011994","sets":["43:81"]},"author_link":["96479"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-09","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23580177　研究代表者：イブラヒム　ヒッシャムラドワ（鹿児島大学・農学部・教授）","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"OTfとサルファ系抗生物質が相互作用してコンプレックスが形成され、サルファ系抗生物質の難水溶性が改善されたことが確認できた。また、サルファ系抗生物質とOTfのコンプレックスは、OTfや抗生物質を単独で用いるよりも、様々な病原菌に対して強い抗菌活性を示した。さらに、OTfは、細菌やヒト細胞の表面に存在するトランスフェリンレセプターに対して、選択的に結合することが明らかにされている。したがって、OTfは、サルファ系抗生物質を細菌または感染された細胞へと運ぶ「キャリアー」として、特異的な新規薬物送達戦略の開発に期待ができる。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"The results demonstrate that ovotransferrin  (OTf) binds different insoluble sulfa antibiotics and for complex in which these hydrophobic antibiotics become totally water soluble. The antibiotics-off complexes showed potent antimicrobial activity against several pathogens or either Gram-positive or Gram-negative strains. Strikingly, the complexes were able to reach and kill pathogens intracellularly infecting human colon cells (HCT-116), and the mechanism was found to be mediated through endocytosis via transferring receptor found at the surface of human cells. The finding herald a fascinating opportunity with potential application of OTf as drug carrier for the treatment of infectious diseases.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23580177"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ヒッシャムラドワ, イブラヒム","creatorNameLang":"ja"},{"creatorName":"HISHAM, RADWAN  Ibrahim","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"23580177.pdf","filesize":[{"value":"5.1 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23580177.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/11994/files/23580177.pdf"},"version_id":"a95ffb31-e263-4160-9d55-a5ed8b2825cc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"食品生化学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug-delivery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-infection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Transferrin receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ovotransferrin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Antimicrobia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"オボトランスフェリンおよびそのドメインを利用した病原体への新規薬物送達戦略の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オボトランスフェリンおよびそのドメインを利用した病原体への新規薬物送達戦略の開発","subitem_title_language":"ja"},{"subitem_title":"Novel anti-infection Drug-delivery strategy by using ovotransferrin and its domains","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["81"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-22"},"publish_date":"2015-05-22","publish_status":"0","recid":"11994","relation_version_is_last":true,"title":["オボトランスフェリンおよびそのドメインを利用した病原体への新規薬物送達戦略の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-04-24T07:02:54.791275+00:00"}