{"created":"2023-07-25T08:03:17.339681+00:00","id":1224,"links":{},"metadata":{"_buckets":{"deposit":"112d3ee2-0071-42a7-ba75-aa7d33d261a1"},"_deposit":{"created_by":18,"id":"1224","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"1224"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00001224","sets":["228:274:4800","64:65"]},"author_link":[],"item_7_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-03-25","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"44","bibliographicPageStart":"35","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"鹿児島大学歯学部紀要","bibliographic_titleLang":"ja"}]}]},"item_7_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2001-03-25","subitem_date_issued_type":"Issued"}]},"item_7_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Tumor blood vessels are different from the normal capilary vessels in point of the function and anatomical form. They supply not only nutrition and oxygn but also anticancer agents in cases of the chemotherapy. Transplanted VX2 carcinoma in the tongue, treated by bleomycin or non-treated, were investigated ultrastructurally, microangiographically, and injection replica scanning electron microscopically. The results obtained experimentally observed with these methods were interpreted to indicate anticancer agent damages the tumor vascular sysytem when intravenous administration repeated. This harmful effect seemed to be an important factor for controling tumor in clinical practice. Therefore, to reduce the damages for the tumor blood vessel, superselective intra-arterial infusion chemotherapy were administrated for the oral cancer. Because only once administration, it is taken the highly concentraion of the anticancer agent in the tumor tissue and lesser damages for the blood vessels. In adittion, hyperfractionated radiotherapy was combined with simultaneously. This therapy was peroformed on 16 patients. When the irradiation dosage reached about 10Gy, intra-arterial infusion chemotherapy was planned. Angiographic images was obtained into the main feeding artery of the tumor via the femoral artery applied by Seldinger's technique at first. The formula of Calvert is clinically usefull to determin the carboplatin dosage. This method had a remarkable antitumor effect and mild adverse reations. Total response rate was calculated as 100%. As to the histopathological effects of 14 cases examined, Grade Iia was 3 cases, and Grade Iib;4,Grade III;2,Grade IV;5 respectively according to the pathological effects on Oboshi-Shimosato's classification. Regarding the relationship between clinicopathological malignancy and effects of this preoperative treatment, the histopathological response tended to diminish as the malignancy grade became higher. Based on these histopathological findings, it showed that the efficacy of this combination therapy for the primary lesions was high. The curability of the surgical procedures subsequent to this therapy was considered to improve the prognosis of the oral cancer.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_7_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03897834","subitem_source_identifier_type":"PISSN"}]},"item_7_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN0035442X","subitem_source_identifier_type":"NCID"}]},"item_7_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_7_subject_20":{"attribute_name":"NIIsubject","attribute_value_mlt":[{"subitem_subject":"歯学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_7_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石神, 哲郎","creatorNameLang":"ja"},{"creatorName":"Ishigami, Tetsuro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"KJ00000165865.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000165865.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/1224/files/KJ00000165865.pdf"},"version_id":"563a3ef0-df78-4fd5-83b8-848a54015389"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"tumor blood vessel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"effect of anticancer agents","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ultrastructural changes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"superselective intra-arterial infusion chemotherappy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"clinico-pathollogical study","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"口腔癌に対する放射線照射併用超選択的動注化学療法の治療効果に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔癌に対する放射線照射併用超選択的動注化学療法の治療効果に関する検討","subitem_title_language":"ja"},{"subitem_title":"Study on the effect of superselective intra-arterial infusion chemotherapy combined with radiation therapy for oral cancer","subitem_title_language":"en"}]},"item_type_id":"7","owner":"18","path":["65","4800"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-03-13"},"publish_date":"2015-03-13","publish_status":"0","recid":"1224","relation_version_is_last":true,"title":["口腔癌に対する放射線照射併用超選択的動注化学療法の治療効果に関する検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-26T07:10:13.025267+00:00"}