@inproceedings{oai:ir.kagoshima-u.ac.jp:00012637,
 author = {Hasui, Kazuhisa and Wang, Jia and Jia, Xinshan and Matsuyama, Takami and Izumo, Shuji and Kawano, Yoshifumi and Kanekura, Takuro and Eizuru, Yoshito and Aozasa, Katsuyuki},
 book = {Proceedings of The 10th Japanese-Korean Lymphoreticular Workshop 2009 and Symposium: Asian Hematopathology},
 month = {2016-10-31},
 note = {Nasal NK/T-cell lymphoma (NKTCL) is an Epstein-Barr virus (EBV)-associated lymphoma
when the close relationship between nasal NKTCL in Japan and EBV infection was elucidated by
Harabuchi et al (Lancet，1990) and the EBV infection in NKTCL is of Latency Ⅱ (Takahara et al.
Human Pathol. 2004). Recently predominant occurrence of nasal NKTCL was observed in China，
even in the northeast region (Zhonghua Bing Li Xue Za Zhi. 2007). This study analyzed
pathoepidemiologically EBV infection in 134 cases of nasopharyngeal lymphomas diagnosed
clinically in the northeast China and investigated immunohistochemically peculiar necrosis in 40
cases of nasopharyngeal lymphomas. Most of 85 cases of T/NK-cell neoplasms (T-ML) were
so-called nasal NKTCL comprising 5 cases of early NKTCL(Polymorphous reticulosis:PR)，65 cases
of NKTCL and 9 cases of cytotoxic T-cell lymphomas.24 of 35 cases of B-cell lymphomas (B-ML)
were of diffuse large B-cell lymphoma (DLBCL) and 9 cases of small cancers were seen. Frequent
occurrence of NKTCL in nasal cavity and in male and frequent occurrcnce of B-ML in pharynx，and
their rare occurrence of B-ML under 40 years of Age were significant. 71 cases of NKTCL were
EBV-associated when 5 cases were not and lymphoma cells with and without EBV infection were
noted in the others. In the residual epithelial lesions in 26 cases of T-ML and 7 cases of B-MLs there
were EBV-not-associated and survivin-positive minute squarmous carcinoma in 11 cases of
EBV-associated NKTCL. EBV-associated NKTCL revealing peculiar necrosis did not show cleaved
casapse-3-positive apoptotic lymphoma cells and expressed survivin，different from the previous reports based on so-called cell line research (Jeon et al.，Ko et al.Lab Invest.2005，2007)，expressed
Beclin-1 (Atg6) and showed macrogranular staining of LC3 (Atg8)，suggesting elevated autophagy. In
the peculiar necrosis with naked nucleus-like cell debris，dense nuclear/peri-nuclear staining of LC3
was a hallmark of autophagic cell death. Consequently，EBV-not-associated NKTCL cells and minute
squarmous carcinoma in the NKTCL suggested microenvironmental factors other than EBV in the
occurrence of NKTCL as suggested epidemiologically (Xu et al.Int J Cancer.2007).},
 pages = {40--42},
 publisher = {The Japanese Lymphoreticular Study Croup, Fukushima, Japan.},
 title = {Pathoepidemiology of Epstein-Barr virus infection and peculiar necrosis in nasal NK/T-cell lymphomas in northeast China.},
 year = {}
}