{"created":"2023-07-25T08:12:19.547416+00:00","id":12637,"links":{},"metadata":{"_buckets":{"deposit":"21542a43-4913-4528-a9c2-74a3b3ca2b5c"},"_deposit":{"created_by":3,"id":"12637","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"12637"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00012637","sets":[]},"author_link":["118816","118817","118826","118829","118818","118819","118820","118827","118825","118821","118828","118831","118824","118830","118832","118822","118823","118833"],"item_13_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicPageEnd":"42","bibliographicPageStart":"40","bibliographic_titles":[{"bibliographic_title":"Proceedings of The 10th Japanese-Korean Lymphoreticular Workshop 2009 and Symposium: Asian Hematopathology"}]}]},"item_13_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-12-01"}]},"item_13_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Nasal NK/T-cell lymphoma (NKTCL) is an Epstein-Barr virus (EBV)-associated lymphoma\nwhen the close relationship between nasal NKTCL in Japan and EBV infection was elucidated by\nHarabuchi et al (Lancet，1990) and the EBV infection in NKTCL is of Latency Ⅱ (Takahara et al.\nHuman Pathol. 2004). Recently predominant occurrence of nasal NKTCL was observed in China，\neven in the northeast region (Zhonghua Bing Li Xue Za Zhi. 2007). This study analyzed\npathoepidemiologically EBV infection in 134 cases of nasopharyngeal lymphomas diagnosed\nclinically in the northeast China and investigated immunohistochemically peculiar necrosis in 40\ncases of nasopharyngeal lymphomas. Most of 85 cases of T/NK-cell neoplasms (T-ML) were\nso-called nasal NKTCL comprising 5 cases of early NKTCL(Polymorphous reticulosis:PR)，65 cases\nof NKTCL and 9 cases of cytotoxic T-cell lymphomas.24 of 35 cases of B-cell lymphomas (B-ML)\nwere of diffuse large B-cell lymphoma (DLBCL) and 9 cases of small cancers were seen. Frequent\noccurrence of NKTCL in nasal cavity and in male and frequent occurrcnce of B-ML in pharynx，and\ntheir rare occurrence of B-ML under 40 years of Age were significant. 71 cases of NKTCL were\nEBV-associated when 5 cases were not and lymphoma cells with and without EBV infection were\nnoted in the others. In the residual epithelial lesions in 26 cases of T-ML and 7 cases of B-MLs there\nwere EBV-not-associated and survivin-positive minute squarmous carcinoma in 11 cases of\nEBV-associated NKTCL. EBV-associated NKTCL revealing peculiar necrosis did not show cleaved\ncasapse-3-positive apoptotic lymphoma cells and expressed survivin，different from the previous reports based on so-called cell line research (Jeon et al.，Ko et al.Lab Invest.2005，2007)，expressed\nBeclin-1 (Atg6) and showed macrogranular staining of LC3 (Atg8)，suggesting elevated autophagy. In\nthe peculiar necrosis with naked nucleus-like cell debris，dense nuclear/peri-nuclear staining of LC3\nwas a hallmark of autophagic cell death. Consequently，EBV-not-associated NKTCL cells and minute\nsquarmous carcinoma in the NKTCL suggested microenvironmental factors other than EBV in the\noccurrence of NKTCL as suggested epidemiologically (Xu et al.Int J Cancer.2007).","subitem_description_type":"Other"}]},"item_13_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"蓮井, 和久"}]},{"nameIdentifiers":[{}],"names":[{"name":"王, 嘉"}]},{"nameIdentifiers":[{}],"names":[{"name":"賈, 心善"}]},{"nameIdentifiers":[{}],"names":[{"name":"松山, 隆美"}]},{"nameIdentifiers":[{}],"names":[{"name":"出雲, 周二"}]},{"nameIdentifiers":[{}],"names":[{"name":"河野, 嘉文"}]},{"nameIdentifiers":[{}],"names":[{"name":"金藏, 拓郎"}]},{"nameIdentifiers":[{}],"names":[{"name":"榮鶴, 義人"}]},{"nameIdentifiers":[{}],"names":[{"name":"青笹, 克之"}]}]},"item_13_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"The Japanese Lymphoreticular Study Croup, Fukushima, Japan."}]},"item_13_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_13_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hasui, Kazuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wang, Jia"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jia, Xinshan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuyama, Takami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Izumo, Shuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawano, Yoshifumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanekura, Takuro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eizuru, Yoshito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aozasa, Katsuyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"Hasui.pdf","filesize":[{"value":"87.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Hasui.pdf","url":"https://ir.kagoshima-u.ac.jp/record/12637/files/Hasui.pdf"},"version_id":"fbc5d5b1-715a-4c5e-a21b-fcaeeef26b8f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Pathoepidemiology of Epstein-Barr virus infection and peculiar necrosis in nasal NK/T-cell lymphomas in northeast China.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pathoepidemiology of Epstein-Barr virus infection and peculiar necrosis in nasal NK/T-cell lymphomas in northeast China."}]},"item_type_id":"13","owner":"3","path":["153"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-03-15"},"publish_date":"2011-03-15","publish_status":"0","recid":"12637","relation_version_is_last":true,"title":["Pathoepidemiology of Epstein-Barr virus infection and peculiar necrosis in nasal NK/T-cell lymphomas in northeast China."],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:21:06.249223+00:00"}