{"created":"2023-07-25T08:12:22.797843+00:00","id":12709,"links":{},"metadata":{"_buckets":{"deposit":"c8029245-5556-4e56-bd74-78a44f593575"},"_deposit":{"created_by":3,"id":"12709","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"12709"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00012709","sets":[]},"author_link":["74435","74434","59777"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Hypoxia-inducible factor -1 is not associated with the clinical course of aplastic anemia in children"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"サイセイ フリョウセイ ヒンケツ ニオケル HIF-1α オ カイシタ VEGF ノ チョウセツ キコウ ノ カイメイ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-03-31"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2010年度科学研究費補助金(若手研究(B))研究成果報告書 課題番号：21790999　研究代表者：児玉祐一 (鹿児島大学医学部・歯学部附属病院医員)","subitem_description_type":"Other"},{"subitem_description":"再生不良性貧血の進行に血小板内のVEGFが関与していることを以前証明したが、今回VEGFの転写因子であるHIF-1αが再生不良性貧血の進行に関与しているかを評価した。再生不良性貧血患者の骨髄の有核細胞を用いてHIF-1αのmRNAの発現量を評価したが、急性に進行する患者と慢性に進行する患者では有意差はなかった。VEGFには別の因子が働いている可能性があることを示唆した。今後巨核球を用いた実験系を確立する予定である。","subitem_description_type":"Other"},{"subitem_description":"We assessed the level of hypoxia-inducible factor-1alpha (HIF-1α), which is known to be a transcription factor of VEGF. The mRNA levels of HIF-1α in bone marrow mononuclear cells (BMMC) were measured by real-time PCR in 13 aplastic anemia (AA) patients. HIF-1α in chronic AA patients was not significantly greater than that in acute AA patients. These data indicated that a high level of HIF-1α in chronic AA does not cause the high level of VEGF in a single platelet in chronic AA. The mRNA of HIF-1α in megakaryocytes should be analyzed to better understand the role of HIF-1α in AA.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"コダマ, ユウイチ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"KODAMA, Yuichi"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21790999"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"児玉, 祐一"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-31"}],"displaytype":"detail","filename":"21790999seika.pdf","filesize":[{"value":"231.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"21790999seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/12709/files/21790999seika.pdf"},"version_id":"5c82a312-e477-42c5-89d8-e8833a3df64a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"小児血液学","subitem_subject_scheme":"Other"},{"subitem_subject":"VEGF","subitem_subject_scheme":"Other"},{"subitem_subject":"再生不良性貧血","subitem_subject_scheme":"Other"},{"subitem_subject":"HIF-1α","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"再生不良性貧血におけるHIF-1αを介したVEGFの調節機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"再生不良性貧血におけるHIF-1αを介したVEGFの調節機構の解明"}]},"item_type_id":"8","owner":"3","path":["83"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"12709","relation_version_is_last":true,"title":["再生不良性貧血におけるHIF-1αを介したVEGFの調節機構の解明"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-01-29T08:29:04.098602+00:00"}