@misc{oai:ir.kagoshima-u.ac.jp:00012761,
 author = {村尾, 光治 and Murao, Koji},
 month = {},
 note = {Effects of methylmercuric chloride (MMC) on the brain acetylcholine (ACh) levels and operant behavior were investigated in rats and mice. Acquisition of T-maze or shuttle box aviodance behaviors was significantly suppresscd in mice，after daily administration of MMC (6mg/kg/day p.o.) for scvcn days. ACh levels in the hippocampus was decreased in mice even 3 hours after single oral dose of MMC (6mg/kg). After 3 days of the treatment with MMC (6mg/kg p.o.，6 successive days)，ACh levels in all regions tested (cerebral cortex， cerebellum，hippocampus，corpus striatum， diencephalonmesencephalon and pons medulla)were significantly decreased in mice. In vitro study， ACh release from hippocampal slice of MMC treated (6mg/kg p.o.) mice was significantly enhanced by high potassium stimulation. In rats，daily oral administration of MMC (5mg/kg) for 10 successive days produced significant decrease of ACh levels in 5 regions without pons medulla， and suppressed the retrieval in conditioned avoidance behavior (Sidman type). In vivo microdialysis study，ACh release from rats corpus striatum was significantly enhanced by MMC (10^{-4}M) contained perfusate. From these results， it is concluded that oral administration of MMC decreascd brain ACh levels and suppressed
conditioned avoidance behavior in rats and mice., 医歯学総合研究科博士論文(医学) ; 学位取得日: 平成8年12月2日},
 title = {脳内アセチルコリンおよび条件行動に及ぼすメチル水銀の影響},
 year = {1996},
 yomi = {ムラオ, コウジ}
}